| pubmed-article:16998187 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0033413 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C1517336 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0037633 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C1382100 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:16998187 | lifeskim:mentions | umls-concept:C0205431 | lld:lifeskim |
| pubmed-article:16998187 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:16998187 | pubmed:dateCreated | 2006-11-3 | lld:pubmed |
| pubmed-article:16998187 | pubmed:abstractText | BCL2 protein functions as an inhibitor of cell apoptosis and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the P1 promoter plays an important role in the transcriptional regulation of BCL2. Here we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K+ solution. This well-defined mixed parallel/antiparallel-stranded G-quadruplex structure contains three G-tetrads of mixed G-arrangements, which are connected with two lateral loops and one side loop, and four grooves of different widths. The three loops interact with the core G-tetrads in a specific way that defines and stabilizes the overall G-quadruplex structure. The loop conformations are in accord with the experimental mutation and footprinting data. The first 3-nt loop adopts a lateral loop conformation and appears to determine the overall folding of the BCL2 G-quadruplex. The third 1-nt double-chain-reversal loop defines another example of a stable parallel-stranded structural motif using the G3NG3 sequence. Significantly, the distinct major BCL2 promoter G-quadruplex structure suggests that it can be specifically involved in gene modulation and can be an attractive target for pathway-specific drug design. | lld:pubmed |
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| pubmed-article:16998187 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16998187 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16998187 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16998187 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16998187 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16998187 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16998187 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:16998187 | pubmed:author | pubmed-author:HurleyLaurenc... | lld:pubmed |
| pubmed-article:16998187 | pubmed:author | pubmed-author:JonesRoger... | lld:pubmed |
| pubmed-article:16998187 | pubmed:author | pubmed-author:YangDanzhouD | lld:pubmed |
| pubmed-article:16998187 | pubmed:author | pubmed-author:DingChenC | lld:pubmed |
| pubmed-article:16998187 | pubmed:author | pubmed-author:DaiJixunJ | lld:pubmed |
| pubmed-article:16998187 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16998187 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:16998187 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16998187 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16998187 | pubmed:pagination | 5133-44 | lld:pubmed |
| pubmed-article:16998187 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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