| pubmed-article:1699811 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1699811 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:1699811 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1699811 | lifeskim:mentions | umls-concept:C0043227 | lld:lifeskim |
| pubmed-article:1699811 | lifeskim:mentions | umls-concept:C0183210 | lld:lifeskim |
| pubmed-article:1699811 | lifeskim:mentions | umls-concept:C0439834 | lld:lifeskim |
| pubmed-article:1699811 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:1699811 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:1699811 | pubmed:dateCreated | 1990-12-13 | lld:pubmed |
| pubmed-article:1699811 | pubmed:abstractText | Calcitonin (CT)-secreting cells (C-cells) are remarkably sensitive to changes in the extracellular Ca2+ concentration. In order to detect the mechanism by which C-cells monitor Ca2+, we compared a C-cell line responding to Ca2+ (rMTC cells) with another one known to have a defect in this Ca2+ signal transduction (TT cells). Rises of the Ca2+ concentration caused rMTC cells to depolarize and/or elicited spontaneous action potentials. Under voltage-clamp conditions, rMTC cells showed a slowly decaying Ca2+ inward current which was sensitive to dihydropyridines but not to Ni2+ at a low concentration. In contrast, the 'defective' TT cells neither depolarized nor fired action potentials with high Ca2+; they only exhibited an Ni2(+)-sensitive, transient Ca2+ current. The data strongly suggest that the slowly inactivating Ca2+ current is a prerequisite for Ca2(+)-sensitivity of C-cells and that fast inactivating channels are not sufficient to act as sensors of the extracellular Ca2+ concentration. | lld:pubmed |
| pubmed-article:1699811 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1699811 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1699811 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1699811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1699811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1699811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1699811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1699811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1699811 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1699811 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1699811 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:1699811 | pubmed:author | pubmed-author:SchultzGG | lld:pubmed |
| pubmed-article:1699811 | pubmed:author | pubmed-author:HeschelerJJ | lld:pubmed |
| pubmed-article:1699811 | pubmed:author | pubmed-author:ScherüblHH | lld:pubmed |
| pubmed-article:1699811 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1699811 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:1699811 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:1699811 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1699811 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1699811 | pubmed:pagination | 51-4 | lld:pubmed |
| pubmed-article:1699811 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:meshHeading | pubmed-meshheading:1699811-... | lld:pubmed |
| pubmed-article:1699811 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1699811 | pubmed:articleTitle | A slowly inactivating calcium current works as a calcium sensor in calcitonin-secreting cells. | lld:pubmed |
| pubmed-article:1699811 | pubmed:affiliation | Pharmakologisches Institut der Freien Universität Berlin, FRG. | lld:pubmed |
| pubmed-article:1699811 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1699811 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1699811 | lld:pubmed |
