| pubmed-article:16987986 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C0042774 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C0063690 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:16987986 | lifeskim:mentions | umls-concept:C0767950 | lld:lifeskim |
| pubmed-article:16987986 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:16987986 | pubmed:dateCreated | 2006-11-13 | lld:pubmed |
| pubmed-article:16987986 | pubmed:abstractText | We initially identified lens epithelium-derived growth factor/p75 (LEDGF/p75) as a binding partner of human immunodeficiency virus type 1 (HIV-1) integrase. To investigate the role of LEDGF/p75 in HIV replication and its potential as a new antiviral target, we stably overexpressed two different fragments containing the integrase binding domain (IBD) of LEDGF/p75 fused to enhanced green fluorescent protein (eGFP). HIV-1 replication was severely inhibited by overexpression of the eGFP-IBD fusion proteins, while no inhibition was observed in cell lines overexpressing the interaction-deficient D366A mutant. Quantitative PCR pinpointed the block to the integration step, whereas nuclear import was not affected. Competition of the IBD fusion proteins with endogenous LEDGF/p75 for binding to integrase led to a potent defect in HIV-1 replication in both HeLaP4- and MT-4-derived cell lines. A previously described diketo acid-resistant HIV-1 strain remained fully susceptible to inhibition, suggesting that this strategy will also work in patients who harbor strains resistant to the current experimental integrase inhibitors. These data support LEDGF/p75 as an important cofactor for HIV replication and provide proof of concept for the LEDGF/p75-integrase interaction as a novel target for treating HIV-1 infection. | lld:pubmed |
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| pubmed-article:16987986 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16987986 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16987986 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16987986 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16987986 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:16987986 | pubmed:author | pubmed-author:DebyserZegerZ | lld:pubmed |
| pubmed-article:16987986 | pubmed:author | pubmed-author:EngelborghsYv... | lld:pubmed |
| pubmed-article:16987986 | pubmed:author | pubmed-author:VercammenJoJ | lld:pubmed |
| pubmed-article:16987986 | pubmed:author | pubmed-author:GijsbersRikR | lld:pubmed |
| pubmed-article:16987986 | pubmed:author | pubmed-author:De RijckJanJ | lld:pubmed |
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| pubmed-article:16987986 | pubmed:author | pubmed-author:ChristFraukeF | lld:pubmed |
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| pubmed-article:16987986 | pubmed:author | pubmed-author:HendrixJelleJ | lld:pubmed |
| pubmed-article:16987986 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16987986 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:16987986 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16987986 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16987986 | pubmed:pagination | 11498-509 | lld:pubmed |
| pubmed-article:16987986 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16987986 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16987986 | pubmed:articleTitle | Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication. | lld:pubmed |
| pubmed-article:16987986 | pubmed:affiliation | Molecular Medicine, KU Leuven and IRC KULAK, Kapucijnenvoer 33 VCTB+5, B-3000 Leuven, Belgium. | lld:pubmed |
| pubmed-article:16987986 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16987986 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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