| pubmed-article:16987978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C0029005 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C1421249 | lld:lifeskim |
| pubmed-article:16987978 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16987978 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:16987978 | pubmed:dateCreated | 2006-11-13 | lld:pubmed |
| pubmed-article:16987978 | pubmed:abstractText | Epstein-Barr virus (EBV) establishes a persistent infection in the human host and is associated with a variety of human cancers. Persistent infection results from a balance between the host immune response and viral immune evasion mechanisms. EBV infection is controlled initially by the innate immune response and later by T-cell-mediated adaptive immunity. EBV has evolved mechanisms to evade the host immune response so that it can persist for the lifetime of the host. Latent membrane protein 1 (LMP-1) is the EBV oncoprotein essential for B-cell immortalization by EBV. We show here that LMP-1 interacts with Tyk2, a signaling intermediate in the alpha interferon (IFN-alpha) signaling pathway, via a previously uncharacterized LMP-1 signaling domain. LMP-1 prevents Tyk2 phosphorylation and inhibits IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity. Long-term culture of EBV+ lymphoblastoid cells in IFN-alpha is associated with outgrowth of a population expressing elevated LMP-1 protein levels, suggesting that cells expressing higher levels of LMP-1 survive the antiproliferative selective pressure imposed by IFN-alpha. These results show that LMP-1 can protect EBV+ cells from the IFN-alpha-stimulated antiviral/antiproliferative response and suggest that chronic IFN-alpha treatment may encourage the outgrowth of cells expressing elevated, and therefore potentially oncogenic, LMP-1 levels in EBV+ individuals. | lld:pubmed |
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| pubmed-article:16987978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16987978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16987978 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16987978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16987978 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16987978 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:16987978 | pubmed:author | pubmed-author:MartinJennife... | lld:pubmed |
| pubmed-article:16987978 | pubmed:author | pubmed-author:GeigerTimothy... | lld:pubmed |
| pubmed-article:16987978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16987978 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:16987978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16987978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16987978 | pubmed:pagination | 11638-50 | lld:pubmed |
| pubmed-article:16987978 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:meshHeading | pubmed-meshheading:16987978... | lld:pubmed |
| pubmed-article:16987978 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16987978 | pubmed:articleTitle | The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells. | lld:pubmed |
| pubmed-article:16987978 | pubmed:affiliation | Department of Molecular, Cellular and Developmental Biology, University of Colorado, Campus Box 347, Boulder, CO 80309, USA. | lld:pubmed |
| pubmed-article:16987978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16987978 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
