| pubmed-article:16979590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C0935640 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C1623048 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C0080125 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C1422036 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:16979590 | lifeskim:mentions | umls-concept:C0178887 | lld:lifeskim |
| pubmed-article:16979590 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16979590 | pubmed:dateCreated | 2006-9-27 | lld:pubmed |
| pubmed-article:16979590 | pubmed:abstractText | The baculovirus has recently emerged as a promising vector for in vivo gene therapy. To investigate its potential as a delivery vector for an anti-virus ribozyme targeting HIV-1, we constructed recombinant baculovirus vectors bearing a ribozyme-synthesizing cassette driven by the tRNA(i)(Met) promoter with enhanced transduction efficiency by displaying vesicular stomatitis virus glycoprotein (VSV-G) on the viral envelope. Transduction of HeLa CD4(+) cells with a recombinant baculovirus delivering the HIV-1 U5 gene-specific ribozyme dramatically suppressed HIV-1 expression in this cell line. The VSV-G pseudotyped baculovirus vector-transduced ribozyme potently inhibited HIV-1 replication compared to a recombinant baculovirus vector-transduced ribozyme lacking VSV-G. The use of a baculovirus vector might be beneficial for application in gene therapy. | lld:pubmed |
| pubmed-article:16979590 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16979590 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16979590 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16979590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16979590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16979590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16979590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16979590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16979590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16979590 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16979590 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16979590 | pubmed:author | pubmed-author:AbeTakashiT | lld:pubmed |
| pubmed-article:16979590 | pubmed:author | pubmed-author:Miyano-Kurosa... | lld:pubmed |
| pubmed-article:16979590 | pubmed:author | pubmed-author:TakakuHiroshi... | lld:pubmed |
| pubmed-article:16979590 | pubmed:author | pubmed-author:SuzukiHitoshi... | lld:pubmed |
| pubmed-article:16979590 | pubmed:author | pubmed-author:KanekoHiroyas... | lld:pubmed |
| pubmed-article:16979590 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16979590 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:16979590 | pubmed:volume | 349 | lld:pubmed |
| pubmed-article:16979590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16979590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16979590 | pubmed:pagination | 1220-7 | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:meshHeading | pubmed-meshheading:16979590... | lld:pubmed |
| pubmed-article:16979590 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16979590 | pubmed:articleTitle | Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vector-transduced ribozyme in mammalian cells. | lld:pubmed |
| pubmed-article:16979590 | pubmed:affiliation | Department of Life and Environmental Science, Faculty of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan. | lld:pubmed |
| pubmed-article:16979590 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16979590 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16979590 | lld:pubmed |
