| pubmed-article:16973583 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C0684079 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C0019630 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C0230825 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C1749570 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:16973583 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:16973583 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:16973583 | pubmed:dateCreated | 2006-9-15 | lld:pubmed |
| pubmed-article:16973583 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) assembly, budding, and release occur mostly at the plasma membrane in T lymphocytes as well as in established nonlymphoid cell lines, while in macrophages these processes occur primarily in intracellular compartments that harbor late endosomal/multivesicular body (LE/MVB) markers, including human leukocyte antigen DR (HLA-DR). Major histocompatibility complex class II molecules (MHC-II), which are expressed in macrophages and activated T cells, have been previously reported to induce the formation of multilaminar and multivesicular endocytic MHC-II-like structures analogous to MVB upon their expression in HEK 293 cells. Here, we have examined the role of MHC-II in HIV-1 Gag targeting as well as in virus assembly and release. Expression of HLA-DR in nonlymphoid cell lines induced a relocation of Gag to intracellular compartments that harbored LE/MVB markers and increased the accumulation of viral particles assembling intracellularly. Consequently, viral production and release from the cell surface was found to be substantially decreased in HLA-DR-expressing cells. This process was specific, since it was not observed with HLA-DR molecules lacking their cytoplasmic tails, nor with structurally related but functionally distinct MHC-II molecules such as HLA-DM or HLA-DO. Importantly, virus released intracellularly in HLA-DR-expressing cells retained infectivity. Overall, these results suggest a role of MHC-II molecules in promoting HIV-1 assembly and budding to LE/MVB and raise the possibility that this activity might be part of a normal pathway of virus production in cell types physiologically expressing MHC-II molecules, such as macrophages. | lld:pubmed |
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| pubmed-article:16973583 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16973583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16973583 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16973583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16973583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16973583 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16973583 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16973583 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:16973583 | pubmed:author | pubmed-author:ThibodeauJacq... | lld:pubmed |
| pubmed-article:16973583 | pubmed:author | pubmed-author:CohenEric AEA | lld:pubmed |
| pubmed-article:16973583 | pubmed:author | pubmed-author:XiaoYongY | lld:pubmed |
| pubmed-article:16973583 | pubmed:author | pubmed-author:FinziAndrésA | lld:pubmed |
| pubmed-article:16973583 | pubmed:author | pubmed-author:BrunetAlexand... | lld:pubmed |
| pubmed-article:16973583 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16973583 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:16973583 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16973583 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16973583 | pubmed:pagination | 9789-97 | lld:pubmed |
| pubmed-article:16973583 | pubmed:dateRevised | 2010-4-29 | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:meshHeading | pubmed-meshheading:16973583... | lld:pubmed |
| pubmed-article:16973583 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16973583 | pubmed:articleTitle | Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments. | lld:pubmed |
| pubmed-article:16973583 | pubmed:affiliation | Unité de Rétrovirologie Humaine, Institut de Recherches Cliniques de Montréal, Montréal, Canada. | lld:pubmed |
| pubmed-article:16973583 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16973583 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
