| pubmed-article:16966600 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16966600 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16966600 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:16966600 | lifeskim:mentions | umls-concept:C1517512 | lld:lifeskim |
| pubmed-article:16966600 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:16966600 | pubmed:dateCreated | 2006-9-20 | lld:pubmed |
| pubmed-article:16966600 | pubmed:abstractText | Type 1A diabetes (T1D) is an autoimmune disorder the risk of which is increased by specific HLA DR/DQ alleles [e.g., DRB1*03-DQB1*0201 (DR3) or DRB1*04-DQB1*0302 (DR4)]. The genotype associated with the highest risk for T1D is the DR3/4-DQ8 (DQ8 is DQA1*0301, DQB1*0302) heterozygous genotype. We determined HLA-DR and -DQ genotypes at birth and analyzed DR3/4-DQ8 siblings of patients with T1D for identical-by-descent HLA haplotype sharing (the number of haplotypes inherited in common between siblings). The children were clinically followed with prospective measurement of anti-islet autoimmunity and for progression to T1D. Risk for islet autoimmunity dramatically increased in DR3/4-DQ8 siblings who shared both HLA haplotypes with their diabetic proband sibling (63% by age 7, and 85% by age 15) compared with siblings who did not share both HLA haplotypes with their diabetic proband sibling (20% by age 15, P < 0.01). 55% sharing both HLA haplotypes developed diabetes by age 12 versus 5% sharing zero or one haplotype (P = 0.03). Despite sharing both HLA haplotypes with their proband, siblings without the HLA DR3/4-DQ8 genotype had only a 25% risk for T1D by age 12. The risk for T1D in the DR3/4-DQ8 siblings sharing both HLA haplotypes with their proband is remarkable for a complex genetic disorder and provides evidence that T1D is inherited with HLA-DR/DQ alleles and additional MHC-linked genes both determining major risk. A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity. | lld:pubmed |
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| pubmed-article:16966600 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16966600 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16966600 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16966600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16966600 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16966600 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16966600 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:EisenbarthGeo... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:ErlichHenry... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:BabuSunanda... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:NorrisJill... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:YuLipingL | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:MiaoDongmeiD | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:FainPamela... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:IdeAkaneA | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:RewersMarian... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:BarrigaKather... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:BarkerJennife... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:AlyTheresa... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:JahromiMohame... | lld:pubmed |
| pubmed-article:16966600 | pubmed:author | pubmed-author:FernandoMaria... | lld:pubmed |
| pubmed-article:16966600 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16966600 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:16966600 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:16966600 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16966600 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16966600 | pubmed:pagination | 14074-9 | lld:pubmed |
| pubmed-article:16966600 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
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| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:meshHeading | pubmed-meshheading:16966600... | lld:pubmed |
| pubmed-article:16966600 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16966600 | pubmed:articleTitle | Extreme genetic risk for type 1A diabetes. | lld:pubmed |
| pubmed-article:16966600 | pubmed:affiliation | Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA. | lld:pubmed |
| pubmed-article:16966600 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16966600 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
