Linked Life Data

16963742

Source:http://linkedlifedata.com/resource/pubmed/id/16963742

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16963742rdf:typepubmed:Citationlld:pubmed
pubmed-article:16963742lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:16963742lifeskim:mentionsumls-concept:C0026844lld:lifeskim
pubmed-article:16963742lifeskim:mentionsumls-concept:C0079323lld:lifeskim
pubmed-article:16963742lifeskim:mentionsumls-concept:C1135918lld:lifeskim
pubmed-article:16963742lifeskim:mentionsumls-concept:C0007585lld:lifeskim
pubmed-article:16963742lifeskim:mentionsumls-concept:C0301630lld:lifeskim
pubmed-article:16963742pubmed:issuePt 10lld:pubmed
pubmed-article:16963742pubmed:dateCreated2006-9-11lld:pubmed
pubmed-article:16963742pubmed:abstractTextHuman cytomegalovirus (HCMV) infection appears to be linked to the pathogenesis of atherosclerosis. An association between HCMV infection and an enhanced restenosis rate as well as the induction of vasculopathies after solid organ transplantation has been documented. Knowledge of the cellular and molecular basis of these findings is limited, however. By Northern blot and RT-PCR analysis of human foreskin fibroblasts (HFF) and human coronary artery smooth muscle cells (SMC), we identified extracellular matrix (ECM) genes that were downregulated after HCMV infection, including collagen type I and fibronectin. Quantitative immunoassays showed a significant reduction of soluble collagen type I and fibronectin proteins in supernatants of both cell types. This was shown to be a direct effect of HCMV infection and not due to a response to interferons released from infected cells, since neutralization of alpha and beta interferon activity could not block virus-induced downregulation of matrix proteins. As the amount of ECM depends on both synthesis and degradation, we also assessed the influence of HCMV on the activity of matrix metalloproteinases (MMP). Interestingly, a significant difference in virus-induced matrix degradation could be shown between the two cell types. HCMV upregulated MMP-2 protein and activity in SMC but not in HFF. Thus, HCMV infection of SMC reduces ECM dramatically by inducing two independent mechanisms that influence synthesis as well as degradation of ECM. These may represent molecular mechanisms for HCMV-induced pathogenesis of inflammatory vasculopathies and may facilitate dissemination of HCMV by promoting the detachment of infected cells in vivo.lld:pubmed
pubmed-article:16963742pubmed:languageenglld:pubmed
pubmed-article:16963742pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16963742pubmed:citationSubsetIMlld:pubmed
pubmed-article:16963742pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16963742pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16963742pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16963742pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16963742pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16963742pubmed:statusMEDLINElld:pubmed
pubmed-article:16963742pubmed:monthOctlld:pubmed
pubmed-article:16963742pubmed:issn0022-1317lld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:MichelDetlefDlld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:MertensThomas...lld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:WaltherPaulPlld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:Schaarschmidt...lld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:WinklerMichae...lld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:ReinhardtBarb...lld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:ZhouShaoxiaSlld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:Schmid-Kotsas...lld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:BachemMaxMlld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:VaidaBiancaBlld:pubmed
pubmed-article:16963742pubmed:authorpubmed-author:PretschRobert...lld:pubmed
pubmed-article:16963742pubmed:issnTypePrintlld:pubmed
pubmed-article:16963742pubmed:volume87lld:pubmed
pubmed-article:16963742pubmed:ownerNLMlld:pubmed
pubmed-article:16963742pubmed:authorsCompleteYlld:pubmed
pubmed-article:16963742pubmed:pagination2849-58lld:pubmed
pubmed-article:16963742pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:meshHeadingpubmed-meshheading:16963742...lld:pubmed
pubmed-article:16963742pubmed:year2006lld:pubmed
pubmed-article:16963742pubmed:articleTitleHuman cytomegalovirus-induced reduction of extracellular matrix proteins in vascular smooth muscle cell cultures: a pathomechanism in vasculopathies?lld:pubmed
pubmed-article:16963742pubmed:affiliationInstitute of Virology, Department of Clinical Chemistry, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.lld:pubmed
pubmed-article:16963742pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16963742pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16963742lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16963742lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16963742lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16963742lld:pubmed