| pubmed-article:16960115 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0015024 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0030664 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0041307 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:16960115 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:16960115 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16960115 | pubmed:dateCreated | 2006-9-8 | lld:pubmed |
| pubmed-article:16960115 | pubmed:abstractText | Bovine tuberculosis is a major economic problem and a potential public health risk. Improved diagnostics like the gamma interferon (IFN-gamma) test with ESAT6 and/or CFP10 could contribute to the control program. We assessed IFN-gamma responses in zebu (Ethiopian Arsi breed) and Holstein cattle kept indoors or in a pasture to tuberculin purified protein derivative (PPD) and an ESAT6-CFP10 protein cocktail. Furthermore, the intensity and distribution of pathology of bovine tuberculosis were compared between the two breeds. Our data demonstrated significantly (all P < 0.02) higher IFN-gamma responses to avian PPD, bovine PPD, and the ESAT6-CFP10 protein cocktail in Holstein than in zebu cattle, while lesion severities in infected animals and tuberculin skin test responses did not differ significantly (P > 0.05) between the two breeds. Holstein cattle that were kept indoors produced significantly (all P < 0.01) higher IFN-gamma levels in response to avian PPD, bovine PPD, and the ESAT6-CFP10 protein cocktail than did Holstein cattle kept in a pasture. Moreover, lesion severity was significantly higher in Holstein cattle kept indoors (P = 0.001) than in those kept in the pasture. Lesions were localized predominantly in the digestive tract in cattle kept in a pasture, while they were localized in the respiratory tract in cattle kept indoors. In conclusion, in Holstein cattle, husbandry was a dominant factor influencing the severity of tuberculosis lesions and IFN-gamma responses to mycobacterial antigens compared to breed. A difference in the cellular immune response between zebu and Holstein cattle was observed, while tuberculosis lesion severities were identical in the two breeds, when both were kept in a pasture. | lld:pubmed |
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| pubmed-article:16960115 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16960115 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16960115 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16960115 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16960115 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16960115 | pubmed:issn | 1556-6811 | lld:pubmed |
| pubmed-article:16960115 | pubmed:author | pubmed-author:HewinsonGlynG | lld:pubmed |
| pubmed-article:16960115 | pubmed:author | pubmed-author:YoungDouglasD | lld:pubmed |
| pubmed-article:16960115 | pubmed:author | pubmed-author:EngersHowardH | lld:pubmed |
| pubmed-article:16960115 | pubmed:author | pubmed-author:AseffaAbraham... | lld:pubmed |
| pubmed-article:16960115 | pubmed:author | pubmed-author:AmeniGobenaG | lld:pubmed |
| pubmed-article:16960115 | pubmed:author | pubmed-author:VordermeierMa... | lld:pubmed |
| pubmed-article:16960115 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16960115 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16960115 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16960115 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16960115 | pubmed:pagination | 1030-6 | lld:pubmed |
| pubmed-article:16960115 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:meshHeading | pubmed-meshheading:16960115... | lld:pubmed |
| pubmed-article:16960115 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16960115 | pubmed:articleTitle | Cattle husbandry in Ethiopia is a predominant factor affecting the pathology of bovine tuberculosis and gamma interferon responses to mycobacterial antigens. | lld:pubmed |
| pubmed-article:16960115 | pubmed:affiliation | Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia. gobenaameni@yahoo.com | lld:pubmed |
| pubmed-article:16960115 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16960115 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16960115 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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