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pubmed-article:16953889pubmed:abstractTextMore than 12,000 simple sequence repeats (SSRs) have been identified in the genome of Burkholderia mallei ATCC 23344. As a demonstrated mechanism of phase variation in other pathogenic bacteria, these may function as mutable loci leading to altered protein expression or structure variation. To determine if such alterations are occurring in vivo, the genomes of various single-colony passaged B. mallei ATCC 23344 isolates, one from each source, were sequenced from culture, a mouse, a horse, and two isolates from a single human patient, and the sequence compared to the published B. mallei ATCC 23344 genome sequence.lld:pubmed
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pubmed-article:16953889pubmed:articleTitleGenome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts.lld:pubmed
pubmed-article:16953889pubmed:affiliationThe Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. cromero@mail.ucf.edulld:pubmed
pubmed-article:16953889pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16953889pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16953889pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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