| pubmed-article:16953513 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16953513 | lifeskim:mentions | umls-concept:C0441833 | lld:lifeskim |
| pubmed-article:16953513 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:16953513 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16953513 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:16953513 | lifeskim:mentions | umls-concept:C1999270 | lld:lifeskim |
| pubmed-article:16953513 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:16953513 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:16953513 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:16953513 | pubmed:dateCreated | 2006-11-22 | lld:pubmed |
| pubmed-article:16953513 | pubmed:abstractText | Pochonins A-F were recently characterized as six new members of the naturally occurring family of 14-membered resorcylic acid lactones. As there are a high number of ATPase and kinase inhibitors among natural resorcylic lactones, a library based on the pochonin scaffold, with five points of diversity, was prepared which includes diversity beyond that of the natural analogues. The library was synthesized by using solid-supported reagents amenable to automation. Testing the library for its inhibition against a panel of 24 kinases at 10 microM afforded a >14 % hit rate. These results demonstrate the potential of the resorcylides towards the inhibition of therapeutically relevant kinases. | lld:pubmed |
| pubmed-article:16953513 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16953513 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16953513 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16953513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16953513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16953513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16953513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16953513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16953513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16953513 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16953513 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16953513 | pubmed:issn | 0947-6539 | lld:pubmed |
| pubmed-article:16953513 | pubmed:author | pubmed-author:BarluengaSofi... | lld:pubmed |
| pubmed-article:16953513 | pubmed:author | pubmed-author:WinssingerNic... | lld:pubmed |
| pubmed-article:16953513 | pubmed:author | pubmed-author:MoulinEmilieE | lld:pubmed |
| pubmed-article:16953513 | pubmed:author | pubmed-author:TotzkeFrankF | lld:pubmed |
| pubmed-article:16953513 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16953513 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:16953513 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16953513 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16953513 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16953513 | pubmed:pagination | 8819-34 | lld:pubmed |
| pubmed-article:16953513 | pubmed:dateRevised | 2009-8-4 | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:meshHeading | pubmed-meshheading:16953513... | lld:pubmed |
| pubmed-article:16953513 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16953513 | pubmed:articleTitle | Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases. | lld:pubmed |
| pubmed-article:16953513 | pubmed:affiliation | Organic and Bioorganic Chemistry Laboratory, Institut de Science et Ingénierie Supramoléculaires, Université Louis Pasteur-CNRS, 8 allée Gaspard Monge, 67000 Strasbourg, France. | lld:pubmed |
| pubmed-article:16953513 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16953513 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16953513 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
