| pubmed-article:16944520 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16944520 | lifeskim:mentions | umls-concept:C0086168 | lld:lifeskim |
| pubmed-article:16944520 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:16944520 | lifeskim:mentions | umls-concept:C1879746 | lld:lifeskim |
| pubmed-article:16944520 | lifeskim:mentions | umls-concept:C1547011 | lld:lifeskim |
| pubmed-article:16944520 | lifeskim:mentions | umls-concept:C1311713 | lld:lifeskim |
| pubmed-article:16944520 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16944520 | pubmed:dateCreated | 2006-11-13 | lld:pubmed |
| pubmed-article:16944520 | pubmed:abstractText | The design of modified nucleic acid aptamers is improved by considering thermodynamics and kinetics of their association/dissociation processes. Locked Nucleic Acids (LNA) is a promising class of nucleic acid analogs. In this work the thermodynamic and kinetic properties of a LNA quadruplex formed by the TGGGT sequence, containing only conformationally restricted LNA residues, are reported and compared to those of 2'-OMe-RNA (O-RNA) and DNA quadruplexes. The thermodynamic analysis indicates that the sugar-modified quadruplexes (LNA and O-RNA) are stabilized by entropic effects. The kinetic analysis shows that LNA and O-RNA quadruplexes are characterized by a slower dissociation and a faster association with respect to DNA quadruplex. Interestingly, the LNA quadruplex formation process shows a second-order kinetics with respect to single strand concentration and has a negative activation energy. To explain these data, a mechanism for tetramer formation with two intermediate states was proposed. | lld:pubmed |
| pubmed-article:16944520 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16944520 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16944520 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16944520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16944520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16944520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16944520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16944520 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16944520 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16944520 | pubmed:issn | 0006-3525 | lld:pubmed |
| pubmed-article:16944520 | pubmed:author | pubmed-author:RandazzoAnton... | lld:pubmed |
| pubmed-article:16944520 | pubmed:author | pubmed-author:GiancolaConce... | lld:pubmed |
| pubmed-article:16944520 | pubmed:author | pubmed-author:PetracconeLui... | lld:pubmed |
| pubmed-article:16944520 | pubmed:author | pubmed-author:ErraEvaE | lld:pubmed |
| pubmed-article:16944520 | pubmed:copyrightInfo | Copyright 2006 Wiley Periodicals, Inc. | lld:pubmed |
| pubmed-article:16944520 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16944520 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16944520 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:16944520 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16944520 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16944520 | pubmed:pagination | 584-94 | lld:pubmed |
| pubmed-article:16944520 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16944520 | pubmed:meshHeading | pubmed-meshheading:16944520... | lld:pubmed |
| pubmed-article:16944520 | pubmed:meshHeading | pubmed-meshheading:16944520... | lld:pubmed |
| pubmed-article:16944520 | pubmed:meshHeading | pubmed-meshheading:16944520... | lld:pubmed |
| pubmed-article:16944520 | pubmed:meshHeading | pubmed-meshheading:16944520... | lld:pubmed |
| pubmed-article:16944520 | pubmed:meshHeading | pubmed-meshheading:16944520... | lld:pubmed |
| pubmed-article:16944520 | pubmed:meshHeading | pubmed-meshheading:16944520... | lld:pubmed |
| pubmed-article:16944520 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16944520 | pubmed:articleTitle | Energetic aspects of locked nucleic acids quadruplex association and dissociation. | lld:pubmed |
| pubmed-article:16944520 | pubmed:affiliation | Dipartimento di Scienze Farmaceutiche, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy. | lld:pubmed |
| pubmed-article:16944520 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16944520 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16944520 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16944520 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16944520 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16944520 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16944520 | lld:pubmed |
