Linked Life Data

16942794

Source:http://linkedlifedata.com/resource/pubmed/id/16942794

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pubmed-article:16942794pubmed:abstractTextTo date, most mtDNA mutations in cancer have been identified in the control region (D-loop) containing the major promoters. However, almost all studies used one sample per tumor and there is no clear evidence whether metastatic deposits harbor different mtDNA variants. To establish whether different mtDNA variants can be found in the same cancer but at different sites, we analyzed a series of unilateral and bilateral primary epithelial ovarian cancers as well as paired metastatic tumor deposits.lld:pubmed
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pubmed-article:16942794pubmed:year2007lld:pubmed
pubmed-article:16942794pubmed:articleTitleSomatic mitochondrial DNA mutations in primary and metastatic ovarian cancer.lld:pubmed
pubmed-article:16942794pubmed:affiliationGynaecological Cancer Centre and Centre for Translational Oncology, Institute of Cancer and CR-UK Clinical Centre, Barts and The London, Queen Mary's School of Medicine and Dentistry, John Vane Science Centre, London, UK. pvta@sgyn.azm.nllld:pubmed
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