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pubmed-article:16940118pubmed:abstractTextConcentrations above the MIC of caspofungin allow growth of some Candida isolates. A strain demonstrating paradoxical growth was grown in the presence and absence of caspofungin, and the cell wall content was analyzed. Beta-1,3-glucan declined 81% in the presence of caspofungin, as expected. Beta-1,6-glucan declined 73%. Chitin increased 898%, demonstrating a mechanism for paradoxical growth-a rapid shift in the key polymer.lld:pubmed
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pubmed-article:16940118pubmed:articleTitleEscape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.lld:pubmed
pubmed-article:16940118pubmed:affiliationDepartment of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128-2699, USA. stevens@stanford.edulld:pubmed
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