| pubmed-article:16940011 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16940011 | lifeskim:mentions | umls-concept:C0032343 | lld:lifeskim |
| pubmed-article:16940011 | lifeskim:mentions | umls-concept:C0337816 | lld:lifeskim |
| pubmed-article:16940011 | lifeskim:mentions | umls-concept:C0030020 | lld:lifeskim |
| pubmed-article:16940011 | lifeskim:mentions | umls-concept:C2348767 | lld:lifeskim |
| pubmed-article:16940011 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16940011 | pubmed:dateCreated | 2006-8-30 | lld:pubmed |
| pubmed-article:16940011 | pubmed:abstractText | Russian VX (O-isobutyl-S-(2-diethylaminoethyl)methylphosphonothioate) is the structural analogue of VX agent. It differs from VX agent (O-ethyl-S-(2-diisopropylaminoethyl) methylphosphonothioate) by two alkyl groups. The potency of currently available oximes (pralidoxime, obidoxime, HI-6) to reactivate Russian VX-inhibited acetylcholinesterase and to eliminate Russian VX-induced acute toxic effects was evaluated using in vivo methods. In vivo determined percentage of reactivation of Russian VX-inhibited blood and brain acetylcholinesterase in poisoned rats shows that HI-6 seems to be the most efficacious reactivator of Russian VX-inhibited acetylcholinesterase among currently used oximes in the peripheral compartment, whereas no difference between reactivating efficacy of all tested oximes was observed in the central compartment. The oxime HI-6 was also found to be the most efficacious oxime in the elimination of acute lethal toxic effects in Russian VX-poisoned mice among all studied oximes. Thus, the oxime HI-6 seems to be the most suitable oxime for the antidotal treatment of acute poisonings with Russian VX as in the case of VX, sarin, cyclosarin, and soman poisonings. | lld:pubmed |
| pubmed-article:16940011 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16940011 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16940011 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16940011 | pubmed:issn | 1091-5818 | lld:pubmed |
| pubmed-article:16940011 | pubmed:author | pubmed-author:KucaKamilK | lld:pubmed |
| pubmed-article:16940011 | pubmed:author | pubmed-author:KassaJiriJ | lld:pubmed |
| pubmed-article:16940011 | pubmed:author | pubmed-author:JunDanielD | lld:pubmed |
| pubmed-article:16940011 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16940011 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16940011 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16940011 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16940011 | pubmed:pagination | 397-401 | lld:pubmed |
| pubmed-article:16940011 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16940011 | pubmed:articleTitle | The reactivating and therapeutic efficacy of oximes to counteract Russian VX poisonings. | lld:pubmed |
| pubmed-article:16940011 | pubmed:affiliation | Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic. kassa@pmfhk.cz | lld:pubmed |
| pubmed-article:16940011 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16940011 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16940011 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
