pubmed-article:16936218 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0238622 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0537423 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0021655 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
pubmed-article:16936218 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
pubmed-article:16936218 | pubmed:issue | 9 | lld:pubmed |
pubmed-article:16936218 | pubmed:dateCreated | 2006-8-28 | lld:pubmed |
pubmed-article:16936218 | pubmed:abstractText | Transcription factor 7-like 2 (TCF7L2) regulates genes involved in cell proliferation and differentiation. The TCF7L2 gene is located on chromosome 10q25 in a region of replicated linkage to type 2 diabetes. Recently, a microsatellite marker in intron 3 (DG10S478) and five correlated single nucleotide polymorphisms (SNPs) were identified in Icelandic individuals that showed strong association with type 2 diabetes, which was replicated in Danish and European-American cohorts. We genotyped four of the SNPs (rs7901695, rs7903146, rs11196205, and rs12255372) in Amish subjects with type 2 diabetes (n = 137), impaired glucose tolerance (IGT; n = 139), and normal glucose tolerance (NGT; n = 342). We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marginal association for rs7901695 (P = 0.05; odds ratio [OR] 1.51); comparison between NGT control subjects and the combined type 2 diabetes/IGT case group showed strong association with rs7901695 and rs7903146 (P = 0.008-0.01; OR 1.53-1.57) and marginal association with rs11196205 and rs12255372 (P = 0.07 and P = 0.04, respectively). In an expanded set of 698 Amish subjects without diabetes, we found no association with insulin and glucose levels during a 3-h oral glucose tolerance test. We also genotyped these SNPs in nondiabetic, non-Amish subjects (n = 48), in whom intravenous glucose tolerance tests were performed, and found an association between rs7901695 and rs7903146 and insulin sensitivity (P = 0.003 and P = 0.005, respectively) and disposition index (P = 0.04 and P = 0.007, respectively). These data provide replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity. | lld:pubmed |
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pubmed-article:16936218 | pubmed:language | eng | lld:pubmed |
pubmed-article:16936218 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16936218 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:16936218 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16936218 | pubmed:month | Sep | lld:pubmed |
pubmed-article:16936218 | pubmed:issn | 0012-1797 | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:ShuldinerAlan... | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:PollinToni... | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:DamcottColeen... | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:ShenHaiqingH | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:MitchellBraxt... | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:SilverKristi... | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:OttSandra HSH | lld:pubmed |
pubmed-article:16936218 | pubmed:author | pubmed-author:ReinhartLauri... | lld:pubmed |
pubmed-article:16936218 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:16936218 | pubmed:volume | 55 | lld:pubmed |
pubmed-article:16936218 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16936218 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16936218 | pubmed:pagination | 2654-9 | lld:pubmed |
pubmed-article:16936218 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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pubmed-article:16936218 | pubmed:meshHeading | pubmed-meshheading:16936218... | lld:pubmed |
pubmed-article:16936218 | pubmed:year | 2006 | lld:pubmed |
pubmed-article:16936218 | pubmed:articleTitle | Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. | lld:pubmed |
pubmed-article:16936218 | pubmed:affiliation | Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA. cdamcott@medicine.umaryland.edu | lld:pubmed |
pubmed-article:16936218 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:16936218 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
pubmed-article:16936218 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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