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pubmed-article:16933328pubmed:abstractTextAmong the genes that encode the glutathione S-transferase (GST) superfamily of Phase 2 metabolizing enzymes, GSTP1 has the highest expression in the lung. The polymorphic GSTP1 gene encodes glutathione S-transferase pi, which is an enzyme that detoxifies cigarette carcinogens, such as benzo-[a]-pyrene. The variant GSTP1 GG genotype is associated with lower enzymatic activity and higher DNA adduct levels in human lymphocytes compared with the AA genotype.lld:pubmed
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pubmed-article:16933328pubmed:copyrightInfo(c) 2006 American Cancer Society.lld:pubmed
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pubmed-article:16933328pubmed:articleTitleAn association between glutathione S-transferase P1 gene polymorphism and younger age at onset of lung carcinoma.lld:pubmed
pubmed-article:16933328pubmed:affiliationDepartment of Environmental Heath, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts, USA.lld:pubmed
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