| pubmed-article:1693213 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1693213 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:1693213 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:1693213 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:1693213 | lifeskim:mentions | umls-concept:C0012315 | lld:lifeskim |
| pubmed-article:1693213 | lifeskim:mentions | umls-concept:C0202474 | lld:lifeskim |
| pubmed-article:1693213 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1693213 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1693213 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1693213 | pubmed:dateCreated | 1990-7-2 | lld:pubmed |
| pubmed-article:1693213 | pubmed:abstractText | The effects of strychnine (STR) were investigated on K(+)-stimulated 45Ca2(+)-uptake into mouse brain neurons, the contractile activity of spontaneously beating rat atria and on [3H]nitrendipine and [3H]BAY K 8644 binding to dihydropyridine calcium channel antagonist and agonist binding sites on brain and cardiac membranes. STR (10(-6)-10(-4) M) had no effect on neuronal 45Ca2(+)-uptake. When combined at equimolar concentrations (10(-5) M), STR and nifedipine produced a potent (nM) inhibition (40%) of neuronal 45Ca2(+)-uptake. In the spontaneously beating rat atria, STR produced a dose-dependent (10(-7)-3 x 10(-4) M) decrease in chronotropy but did not affect inotropy. STR (10(-4) M) completely inhibited the positive chronotropic, but did not affect the positive inotropic effects of (-)-S-BAY K 8644. [3H]Nitrendipine and [3H]BAY K 8644 binding to brain and cardiac membranes was enhanced by STR in a concentration-dependent manner (EC50 8 X 10(-6) M). Scatchard analysis revealed that STR increased the affinity (decreased the Kd) of [3H]BAY K 8644 to a greater degree than that of [3H]nitrendipine for dihydropyridine binding sites. STR decreased the Kd of [3H]nitrendipine binding by increasing and decreasing the microassociation and microdissociation constants respectively. STR enhanced [3H]nitrendipine binding to the same extent in the cerebral cortex, striatum, hippocampus, cerebellum, brainstem and spinal cord. The enhancement of [3H]nitrendipine binding in brain was completely inhibited by Ca2+ and partially inhibited by Na+ in a concentration-dependent manner. Glycine (10(-2) M) did not affect the STR enhancement of [3H]nitrendipine binding.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1693213 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1693213 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1693213 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1693213 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1693213 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1693213 | pubmed:issn | 0091-3057 | lld:pubmed |
| pubmed-article:1693213 | pubmed:author | pubmed-author:BolgerG TGT | lld:pubmed |
| pubmed-article:1693213 | pubmed:author | pubmed-author:O'NeillS KSK | lld:pubmed |
| pubmed-article:1693213 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1693213 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:1693213 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1693213 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1693213 | pubmed:pagination | 833-40 | lld:pubmed |
| pubmed-article:1693213 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1693213 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1693213 | pubmed:articleTitle | The effects of strychnine on the regulation of voltage-dependent calcium channels by dihydropyridines in brain and heart. | lld:pubmed |
| pubmed-article:1693213 | pubmed:affiliation | Memorial University of Newfoundland, St. John's, Canada. | lld:pubmed |
| pubmed-article:1693213 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1693213 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1693213 | lld:pubmed |
