pubmed-article:16930555 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16930555 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
pubmed-article:16930555 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
pubmed-article:16930555 | lifeskim:mentions | umls-concept:C0290178 | lld:lifeskim |
pubmed-article:16930555 | lifeskim:mentions | umls-concept:C1335227 | lld:lifeskim |
pubmed-article:16930555 | lifeskim:mentions | umls-concept:C1155781 | lld:lifeskim |
pubmed-article:16930555 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:16930555 | pubmed:dateCreated | 2006-9-11 | lld:pubmed |
pubmed-article:16930555 | pubmed:abstractText | Polo-like kinase functions are essential for the establishment of a normal bipolar mitotic spindle, although precisely how Plk1 regulates the spindle is uncertain. In this study, we report that the small GTP/GDP-binding protein Ran is associated with Plk1. Plk1 is capable of phosphorylating co-immunoprecipitated Ran in vitro on serine-135 and Ran is phosphorylated in vivo at the same site during mitosis when Plk1 is normally activated. Cell cultures over-expressing a Ran S135D mutant have significantly higher numbers of abnormal mitotic cells than those over-expressing either wild-type or S135A Ran. The abnormalities in S135D mutant cells are similar to cells over-expressing Plk1. Our data suggests that Ran is a physiological substrate of Plk1 and that Plk1 regulates the spindle organization partially through its phosphorylation on Ran. | lld:pubmed |
pubmed-article:16930555 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16930555 | pubmed:language | eng | lld:pubmed |
pubmed-article:16930555 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16930555 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:16930555 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16930555 | pubmed:month | Oct | lld:pubmed |
pubmed-article:16930555 | pubmed:issn | 0006-291X | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:LongoDan LDL | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:YangFengF | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:ConradsThomas... | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:VeenstraTimot... | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:DimitrovDimit... | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:CopelandTerry... | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:HughesSteveS | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:FisherRebecca... | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:YuanJin HuiJH | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:MaloidSharon... | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:FerrisAndreaA | lld:pubmed |
pubmed-article:16930555 | pubmed:author | pubmed-author:FerrisDouglas... | lld:pubmed |
pubmed-article:16930555 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:16930555 | pubmed:day | 13 | lld:pubmed |
pubmed-article:16930555 | pubmed:volume | 349 | lld:pubmed |
pubmed-article:16930555 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16930555 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16930555 | pubmed:pagination | 144-52 | lld:pubmed |
pubmed-article:16930555 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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pubmed-article:16930555 | pubmed:meshHeading | pubmed-meshheading:16930555... | lld:pubmed |
pubmed-article:16930555 | pubmed:year | 2006 | lld:pubmed |
pubmed-article:16930555 | pubmed:articleTitle | Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation. | lld:pubmed |
pubmed-article:16930555 | pubmed:affiliation | Laboratory of Cancer Prevention, NCI at Frederick, Frederick, MD, USA; Nanobiology Program, CCR, NCI at Frederick, Frederick, MD, USA. yfeng@mail.ncifcrf.gov | lld:pubmed |
pubmed-article:16930555 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:16930555 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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