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pubmed-article:16928711pubmed:abstractTextExogenous doses of 60 mg/kg alpha(1)-antitrypsin (AAT) every 7 days are recommended in patients with severe AAT deficiency. However, long term administration of weekly doses is not well accepted by patients. Using pharmacokinetic simulations, we evaluated whether steady state minimum concentrations of total AAT can be maintained above the threshold of 0.5 g/l with longer intervals between doses.lld:pubmed
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pubmed-article:16928711pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:16928711pubmed:articleTitleAlpha-1-antitrypsin deficiency: optimal therapeutic regimen based on population pharmacokinetics.lld:pubmed
pubmed-article:16928711pubmed:affiliationPharmacy Service, Hospital Clínic, (IDIBAPS), Barcelona, Spain.lld:pubmed
pubmed-article:16928711pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16928711pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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