| pubmed-article:1692763 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C0746922 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C2700445 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C2697524 | lld:lifeskim |
| pubmed-article:1692763 | lifeskim:mentions | umls-concept:C1706163 | lld:lifeskim |
| pubmed-article:1692763 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1692763 | pubmed:dateCreated | 1990-6-25 | lld:pubmed |
| pubmed-article:1692763 | pubmed:abstractText | The lymphocyte subpopulations in tumor-draining lymph nodes of melanoma patients were determined using two-color flow cytometry. Data were analyzed according to: (a) the staging of the melanoma; (b) whether or not the nodes contained tumor; and (c) their distance from the primary tumor. Compared with Stage I patients (without metastasis), uninvolved nodes of stage II patients (with nodal metastases) had a significant decrease in helper/inducer (CD4+) T-cells (P less than 0.001), with a corresponding increase in cytotoxic/suppressor (CD8+) cells (P less than 0.001) and Leu 19+ natural killer (CD56+) cells (P less than 0.01). In some patients the presence of tumor within a node was associated with a large decrease in CD3+ total T-cells, whereas in others tumor involvement had little influence on lymphocyte phenotypes. When analyzed by distance from the primary tumor, nodes closest to tumor in Stage I patients contained a smaller percentage of CD19+ B-cells. In Stage II, tumor-free nodes nearest to tumor showed an increase in CD19+ cells, but statistical significance was not reached. CD56+ natural killer cells increased progressively in nodes near tumor and were more numerous in Stage II uninvolved nodes compared with Stage I nodes. Alterations in phenotypically defined lymph node lymphocytes occur in nodes regional to melanoma as the disease progresses, as growth of metastases occurs, and in tumor-free nodes nearest to tumor. These alterations may be essential to the establishment and progression of metastases. | lld:pubmed |
| pubmed-article:1692763 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1692763 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1692763 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1692763 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1692763 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1692763 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1692763 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1692763 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1692763 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1692763 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1692763 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:1692763 | pubmed:author | pubmed-author:MortonD LDL | lld:pubmed |
| pubmed-article:1692763 | pubmed:author | pubmed-author:McBrideW HWH | lld:pubmed |
| pubmed-article:1692763 | pubmed:author | pubmed-author:CochranA JAJ | lld:pubmed |
| pubmed-article:1692763 | pubmed:author | pubmed-author:WongVV | lld:pubmed |
| pubmed-article:1692763 | pubmed:author | pubmed-author:GrayJ DJD | lld:pubmed |
| pubmed-article:1692763 | pubmed:author | pubmed-author:FarzadZZ | lld:pubmed |
| pubmed-article:1692763 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1692763 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1692763 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:1692763 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1692763 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1692763 | pubmed:pagination | 3585-8 | lld:pubmed |
| pubmed-article:1692763 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1692763 | pubmed:meshHeading | pubmed-meshheading:1692763-... | lld:pubmed |
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| pubmed-article:1692763 | pubmed:meshHeading | pubmed-meshheading:1692763-... | lld:pubmed |
| pubmed-article:1692763 | pubmed:meshHeading | pubmed-meshheading:1692763-... | lld:pubmed |
| pubmed-article:1692763 | pubmed:meshHeading | pubmed-meshheading:1692763-... | lld:pubmed |
| pubmed-article:1692763 | pubmed:meshHeading | pubmed-meshheading:1692763-... | lld:pubmed |
| pubmed-article:1692763 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1692763 | pubmed:articleTitle | Lymphocyte subset alterations in nodes regional to human melanoma. | lld:pubmed |
| pubmed-article:1692763 | pubmed:affiliation | Division of Surgical Oncology, University of California, Los Angeles 90024. | lld:pubmed |
| pubmed-article:1692763 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1692763 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1692763 | lld:pubmed |
