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pubmed-article:16923518pubmed:abstractTextA deficiency of ADAMTS13 leads to platelet clumping and/or thrombi formation, finally resulting in thrombotic thrombocytopenic purpura (TTP). In this study, a 62-year-old male with chronic hepatitis C developed TTP a month after long-term pegylated-interferon (PEG-IFN) treatment. The observed low level of activity of plasma ADAMTS13 following PEG-IFN treatment was shown to gradually increase with the improvement of TTP, while the titer of an inhibitory anti- ADAMTS13 IgG antibody decreased concomitant with the increase in ADAMTS13 activity. Serial determination of ADAMTS13 activity and its inhibitor may provide useful information for the diagnosis and treatment of IFN-associated TTP, as well as its pathogenesis.lld:pubmed
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pubmed-article:16923518pubmed:authorpubmed-author:MatsumotoMasa...lld:pubmed
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pubmed-article:16923518pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:16923518pubmed:articleTitleThrombotic thrombocytopenic purpura associated with pegylated-interferon alpha-2a by an ADAMTS13 inhibitor in a patient with chronic hepatitis C.lld:pubmed
pubmed-article:16923518pubmed:affiliationDepartment of Internal Medicine, Matsumoto National Hospital,Matsumoto, Japan. kiyoshikitano@mac.comlld:pubmed
pubmed-article:16923518pubmed:publicationTypeJournal Articlelld:pubmed
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