| pubmed-article:16921367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16921367 | lifeskim:mentions | umls-concept:C0016719 | lld:lifeskim |
| pubmed-article:16921367 | lifeskim:mentions | umls-concept:C1512474 | lld:lifeskim |
| pubmed-article:16921367 | lifeskim:mentions | umls-concept:C0598496 | lld:lifeskim |
| pubmed-article:16921367 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:16921367 | lifeskim:mentions | umls-concept:C2266853 | lld:lifeskim |
| pubmed-article:16921367 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16921367 | pubmed:dateCreated | 2006-9-19 | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:abstractText | Expansion of GAA x TTC triplets within an intron in FXN (the gene encoding frataxin) leads to transcription silencing, forming the molecular basis for the neurodegenerative disease Friedreich's ataxia. Gene silencing at expanded FXN alleles is accompanied by hypoacetylation of histones H3 and H4 and trimethylation of histone H3 at Lys9, observations that are consistent with a heterochromatin-mediated repression mechanism. We describe the synthesis and characterization of a class of histone deacetylase (HDAC) inhibitors that reverse FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia. We show that these molecules directly affect the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12). This class of HDAC inhibitors may yield therapeutics for Friedreich's ataxia. | lld:pubmed |
| pubmed-article:16921367 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16921367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16921367 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16921367 | pubmed:issn | 1552-4450 | lld:pubmed |
| pubmed-article:16921367 | pubmed:author | pubmed-author:HermanDavidD | lld:pubmed |
| pubmed-article:16921367 | pubmed:author | pubmed-author:GottesfeldJoe... | lld:pubmed |
| pubmed-article:16921367 | pubmed:author | pubmed-author:PerlmanSusan... | lld:pubmed |
| pubmed-article:16921367 | pubmed:author | pubmed-author:SoragniElisab... | lld:pubmed |
| pubmed-article:16921367 | pubmed:author | pubmed-author:BurnettRyanR | lld:pubmed |
| pubmed-article:16921367 | pubmed:author | pubmed-author:JenssenKaiK | lld:pubmed |
| pubmed-article:16921367 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16921367 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:16921367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16921367 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16921367 | pubmed:pagination | 551-8 | lld:pubmed |
| pubmed-article:16921367 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:meshHeading | pubmed-meshheading:16921367... | lld:pubmed |
| pubmed-article:16921367 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16921367 | pubmed:articleTitle | Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. | lld:pubmed |
| pubmed-article:16921367 | pubmed:affiliation | Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. | lld:pubmed |
| pubmed-article:16921367 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16921367 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16921367 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16921367 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16921367 | lld:pubmed |
