| pubmed-article:16920909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16920909 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:16920909 | lifeskim:mentions | umls-concept:C0963088 | lld:lifeskim |
| pubmed-article:16920909 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:16920909 | lifeskim:mentions | umls-concept:C1819439 | lld:lifeskim |
| pubmed-article:16920909 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:16920909 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:16920909 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:16920909 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16920909 | pubmed:dateCreated | 2006-8-21 | lld:pubmed |
| pubmed-article:16920909 | pubmed:abstractText | Although IL-12 and IL-23 share the common p40 subunit, IL-23, rather than IL-12, seems to drive the pathogenesis of experimental autoimmune encephalomyelitis and arthritis, because IL-23/p19 knockout mice are protected from disease. In contrast, we describe in this study that newly created LacZ knockin mice deficient for IL-23 p19 were highly susceptible for the development of experimental T cell-mediated TNBS colitis and showed even more severe colitis than wild-type mice by endoscopic and histologic criteria. Subsequent studies revealed that dendritic cells from p19-deficient mice produce elevated levels of IL-12, and that IL-23 down-regulates IL-12 expression upon TLR ligation. Finally, in vivo blockade of IL-12 p40 in IL-23-deficient mice rescued mice from lethal colitis. Taken together, our data identify cross-regulation of IL-12 expression by IL-23 as novel key regulatory pathway during initiation of T cell dependent colitis. | lld:pubmed |
| pubmed-article:16920909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16920909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16920909 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16920909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16920909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16920909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16920909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16920909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16920909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16920909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16920909 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16920909 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:WirtzStefanS | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:BeckerChristo... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:GallePeter... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:NeurathMarkus... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:YancopoulosGe... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:LehrHans-Anto... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:KarowMargaret... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:ValenzuelaDav... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:MurphyAndrew... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:FantiniMassim... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:NikolaevAlexe... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:DornhoffHeike... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:NeufertClemen... | lld:pubmed |
| pubmed-article:16920909 | pubmed:author | pubmed-author:HuebnerSabine... | lld:pubmed |
| pubmed-article:16920909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16920909 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16920909 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:16920909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16920909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16920909 | pubmed:pagination | 2760-4 | lld:pubmed |
| pubmed-article:16920909 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:meshHeading | pubmed-meshheading:16920909... | lld:pubmed |
| pubmed-article:16920909 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16920909 | pubmed:articleTitle | Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. | lld:pubmed |
| pubmed-article:16920909 | pubmed:affiliation | Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany. | lld:pubmed |
| pubmed-article:16920909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16920909 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16159 | entrezgene:pubmed | pubmed-article:16920909 | lld:entrezgene |
| entrez-gene:16160 | entrezgene:pubmed | pubmed-article:16920909 | lld:entrezgene |
| entrez-gene:83430 | entrezgene:pubmed | pubmed-article:16920909 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16920909 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16920909 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16920909 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16920909 | lld:pubmed |
