| pubmed-article:16919262 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16919262 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:16919262 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16919262 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:16919262 | lifeskim:mentions | umls-concept:C0384553 | lld:lifeskim |
| pubmed-article:16919262 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:16919262 | pubmed:dateCreated | 2006-9-11 | lld:pubmed |
| pubmed-article:16919262 | pubmed:abstractText | The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases. | lld:pubmed |
| pubmed-article:16919262 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16919262 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16919262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919262 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16919262 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16919262 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:IkedaMasahiro... | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:YamasakiShinj... | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:ItoKatsuakiK | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:ShimonoMariko... | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:GunjiYasuhiro... | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:SonodaHirokoH | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:OshikawaSayak... | lld:pubmed |
| pubmed-article:16919262 | pubmed:author | pubmed-author:HorieAtsukoA | lld:pubmed |
| pubmed-article:16919262 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16919262 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:16919262 | pubmed:volume | 546 | lld:pubmed |
| pubmed-article:16919262 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16919262 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16919262 | pubmed:pagination | 36-9 | lld:pubmed |
| pubmed-article:16919262 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:meshHeading | pubmed-meshheading:16919262... | lld:pubmed |
| pubmed-article:16919262 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16919262 | pubmed:articleTitle | Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death. | lld:pubmed |
| pubmed-article:16919262 | pubmed:affiliation | Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Gakuenkibanadai-nishi 1-1, Miyazaki 889-2192, Japan. a0d302u@cc.miyazaki-u.ac.jp | lld:pubmed |
| pubmed-article:16919262 | pubmed:publicationType | Journal Article | lld:pubmed |
