| pubmed-article:1690843 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0043519 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1690843 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:1690843 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1690843 | pubmed:dateCreated | 1990-5-2 | lld:pubmed |
| pubmed-article:1690843 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1690843 | pubmed:abstractText | The zona pellucida surrounds all mammalian oocytes and plays a vital role at fertilization and in early development. The genes that code for two of the mouse zona proteins (ZP2 and ZP3) represent a developmentally regulated set of genes whose expression serves as markers of mouse oocyte growth and differentiation. We previously characterized the single-copy Zp-3 gene and showed that its expression is oocyte specific and restricted to a narrow window of oocyte development. We now define the Zp-2 gene transcript and show that it is coordinately expressed with Zp-3 only during the 2-week growth phase of oogenesis that occurs prior to ovulation. Like Zp-3, the expression of Zp-2 is restricted to oocytes, and, although not detectable in resting oocytes, both ZP2 and ZP3 transcripts accumulate to become very abundant messengers in 50-microns-diameter oocytes. Ovulated eggs contain ZP2 and ZP3 transcripts which are 200 nucleotides shorter than those found in growing oocytes and have an abundance of less than 5% of the peak levels. In an attempt to understand the molecular details associated with the developmentally regulated, tissue-specific gene expression of the zona genes, the Zp-2 genetic locus has been characterized and its 5' flanking sequences have been compared with those of Zp-3. Both genes contain three short (8- to 12-base-pair) DNA sequences of 80 to 88% identity located within 250 base pairs of their transcription start sites. | lld:pubmed |
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| pubmed-article:1690843 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1690843 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1690843 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1690843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1690843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1690843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1690843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1690843 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1690843 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1690843 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1690843 | pubmed:author | pubmed-author:DeanJJ | lld:pubmed |
| pubmed-article:1690843 | pubmed:author | pubmed-author:ChamowS MSM | lld:pubmed |
| pubmed-article:1690843 | pubmed:author | pubmed-author:LiangL FLF | lld:pubmed |
| pubmed-article:1690843 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1690843 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:1690843 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1690843 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1690843 | pubmed:pagination | 1507-15 | lld:pubmed |
| pubmed-article:1690843 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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