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pubmed-article:16908423pubmed:abstractTextAll-Trans Retinoic Acid (ATRA) nanosuspensions were prepared with a modified precipitation method. The ATRA solution in acetone was injected into pure water by an air compressor under the action of ultrasonication. Photon correlation spectroscopy results showed that the mean particle size of ATRA nanoparticles in nanosuspensions reduced from 337 nm to 155 nm as the injection velocity increased and the polydispersity index was 0.45-0.50. The morphology of ATRA nanoparticles varied with the different concentration of ATRA solution in acetone. ATRA nanoparticles showed an amorphous state and stable in 6 months. It could be concluded that this modified precipitation method could produce stable and controllable ATRA nanosuspension to a certain extent, thus benefit for higher saturation solubility.lld:pubmed
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pubmed-article:16908423pubmed:authorpubmed-author:ZhangXXlld:pubmed
pubmed-article:16908423pubmed:authorpubmed-author:XiaQQlld:pubmed
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pubmed-article:16908423pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:16908423pubmed:year2006lld:pubmed
pubmed-article:16908423pubmed:articleTitlePreparation of All-Trans Retinoic Acid nanosuspensions using a modified precipitation method.lld:pubmed
pubmed-article:16908423pubmed:affiliationState Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and Devices, Southeast University, Nanjing, China.lld:pubmed
pubmed-article:16908423pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16908423pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed