| pubmed-article:16908138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0035142 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C1335439 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0021236 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:16908138 | lifeskim:mentions | umls-concept:C0053183 | lld:lifeskim |
| pubmed-article:16908138 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:16908138 | pubmed:dateCreated | 2006-8-25 | lld:pubmed |
| pubmed-article:16908138 | pubmed:abstractText | Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC(50) approximately 50 nM). | lld:pubmed |
| pubmed-article:16908138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16908138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16908138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16908138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16908138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16908138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16908138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16908138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16908138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16908138 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16908138 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:ThauvetteLoui... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:BykowskiDarre... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:McKercherGine... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:KukoljGeorgeG | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:JakalianArazA | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:LagacéLisette... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:BrochuChristi... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:DansereauNath... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:HachéBrunoB | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:BeaulieuPierr... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:GillardJamesJ | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:LaPlanteSteve... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:DuceppeJean-S... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:MoreauElaineE | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:PerreaultStép... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:StammersTimot... | lld:pubmed |
| pubmed-article:16908138 | pubmed:author | pubmed-author:WarringtonJef... | lld:pubmed |
| pubmed-article:16908138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16908138 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16908138 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16908138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16908138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16908138 | pubmed:pagination | 4987-93 | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:meshHeading | pubmed-meshheading:16908138... | lld:pubmed |
| pubmed-article:16908138 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16908138 | pubmed:articleTitle | Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds. | lld:pubmed |
| pubmed-article:16908138 | pubmed:affiliation | Boehringer Ingelheim, Canada, Ltd., Research and Development, 2100 Cunard Street, Laval, Québec, Canada H7S 2G5. pbeaulieu@lav.boehringer-ingelheim.com | lld:pubmed |
| pubmed-article:16908138 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16908138 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16908138 | lld:pubmed |
