Linked Life Data

16904174

Source:http://linkedlifedata.com/resource/pubmed/id/16904174

Statements in which the resource exists.
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pubmed-article:16904174pubmed:abstractTextDifferentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.lld:pubmed
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pubmed-article:16904174pubmed:authorpubmed-author:YamanakaShiny...lld:pubmed
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pubmed-article:16904174pubmed:articleTitleInduction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.lld:pubmed
pubmed-article:16904174pubmed:affiliationDepartment of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.lld:pubmed
pubmed-article:16904174pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16904174pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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