| pubmed-article:16896156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C1554080 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C1706198 | lld:lifeskim |
| pubmed-article:16896156 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16896156 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16896156 | pubmed:dateCreated | 2006-11-20 | lld:pubmed |
| pubmed-article:16896156 | pubmed:abstractText | Our previous results demonstrated that B cells from a patient (pt1) with non-X-linked hyper-IgM syndrome (HIGM) possess an atypical CD23(lo) phenotype that is unaffected by CD40-mediated activation. To investigate the molecular mechanism underlying defective CD23 expression in pt1 B cells, we used lymphoblastoid cell lines that express LMP1 under the control of a tetracycline-inducible promoter (LCL(tet)). Our analysis revealed that the CD23(lo) phenotype in the pt1-LCL(tet) cells is a direct consequence of diminished CD23 transcription. We demonstrate a marked decrease in c-Rel-containing complexes that bind to the proximal CD23a/b promoters in pt1-LCL(tet) extracts, resulting from an overall lower expression of c-Rel in pt1-LCL(tet) cells. Analysis of c-Rel mRNA revealed relatively equal amounts in pt1-LCL(tet) and control LCL(tet) cells, indicating that diminished c-Rel protein expression is unrelated to decreased transcription. Finally, a critical role for c-Rel in CD23 regulation was demonstrated by effectively altering c-Rel expression that resulted in the direct modulation of CD23 surface expression. Collectively, these findings demonstrate that low levels of c-Rel are the underlying cause of aberrant CD23 expression in pt1 B cells and are likely to play a critical role in the pathophysiology of this form of HIGM. | lld:pubmed |
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| pubmed-article:16896156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16896156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16896156 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16896156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16896156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16896156 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16896156 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16896156 | pubmed:author | pubmed-author:LuKristina... | lld:pubmed |
| pubmed-article:16896156 | pubmed:author | pubmed-author:CoveyLori RLR | lld:pubmed |
| pubmed-article:16896156 | pubmed:author | pubmed-author:DryerRebecca... | lld:pubmed |
| pubmed-article:16896156 | pubmed:author | pubmed-author:SongCharlesC | lld:pubmed |
| pubmed-article:16896156 | pubmed:author | pubmed-author:SinquettFrank... | lld:pubmed |
| pubmed-article:16896156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16896156 | pubmed:day | 1 | lld:pubmed |
