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pubmed-article:1689070pubmed:abstractTextThe opening of voltage sensitive calcium channels is an important event in the progression of irreversible shock, allowing the entry of toxic amounts of calcium (Ca2+) into the cells. Because intracellular magnesium (Mg2+) can efflux through these same channels, changes in serum Mg2+ may reflect the patency of these channels. In this study, electrolytes and selected serum enzymes were monitored in chronically instrumented conscious dogs to follow the progression of shock following a fixed volume hemorrhage. Plasma enzymes indicative of liver damage were elevated only in the terminal phase of hemorrhagic decompensation. A significant increase in serum Mg2+ was evident 60 min following hemorrhage, even though arterial pressure was still recovering. Serum Mg2+ continued to rise throughout the recovery and decompensating phases of shock. Verapamil treatment, which increased survival time and survival rate, significantly attenuated the changes in serum Mg2+ which normally followed hemorrhage. These results indicate that serum Mg2+ may be a useful indicator of the severity and the progression of hemorrhagic shock.lld:pubmed
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pubmed-article:1689070pubmed:authorpubmed-author:CarrollR GRGlld:pubmed
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pubmed-article:1689070pubmed:volume19lld:pubmed
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pubmed-article:1689070pubmed:pagination41-52lld:pubmed
pubmed-article:1689070pubmed:dateRevised2009-8-25lld:pubmed
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pubmed-article:1689070pubmed:year1990lld:pubmed
pubmed-article:1689070pubmed:articleTitleSerum magnesium increases following severe hemorrhage in dogs blocked by verapamil treatment.lld:pubmed
pubmed-article:1689070pubmed:affiliationDepartment of Physiology, East Carolina University School of Medicine, Greenville, NC 27858-4354.lld:pubmed
pubmed-article:1689070pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1689070pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed