| pubmed-article:16890406 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16890406 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16890406 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:16890406 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:16890406 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16890406 | pubmed:dateCreated | 2006-10-18 | lld:pubmed |
| pubmed-article:16890406 | pubmed:abstractText | Regulatory T cells have an important role in the control of self-reactivity, and in the pathogenesis of autoimmune inflammatory conditions. The aim of this work was to perform a quantitative and functional analysis of regulatory T cells in patients with systemic lupus erythematosus (SLE). We studied twenty-three patients with SLE (19 active, 4 inactive), and twenty-seven healthy subjects as well as fifteen patients with rheumatoid arthritis (RA). The following cell subsets were analyzed in peripheral blood mononuclear cells by flow cytometry: CD4+CD25+, CD4+CD25(bright), CD4+Foxp3+ (Treg cells), CD8+CD28- (Ts cells), CD4+IL-10+ (Tr1 cells), and CD4+TGF-beta+ (Th3 cells). In addition, the in vitro suppressive activity of CD4+CD25+ lymphocytes was tested. We found no significant differences in the levels of all regulatory cell subsets studied in SLE patients compared to controls and RA patients. However, a defective regulatory function of CD4+CD25+T cells was observed in a significant fraction (31%) of patients with SLE. Our data indicate that although approximately one third of patients with SLE show an abnormal immunosuppressive function of Treg lymphocytes, their levels of the different regulatory T cell subsets in peripheral blood are not significantly different from those found in controls. | lld:pubmed |
| pubmed-article:16890406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16890406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16890406 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16890406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16890406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16890406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16890406 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16890406 | pubmed:issn | 0896-8411 | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:BarandaLourde... | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:González-Amar... | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:Layseca-Espin... | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:Alvarado-Sánc... | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:Portales-Pére... | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:Abud-MendozaC... | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:Hernández-Cas... | lld:pubmed |
| pubmed-article:16890406 | pubmed:author | pubmed-author:Cubillas-Teje... | lld:pubmed |
| pubmed-article:16890406 | pubmed:copyrightInfo | Copyright 2006 Elsevier Ltd. | lld:pubmed |
| pubmed-article:16890406 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16890406 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:16890406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16890406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16890406 | pubmed:pagination | 110-8 | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:meshHeading | pubmed-meshheading:16890406... | lld:pubmed |
| pubmed-article:16890406 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16890406 | pubmed:articleTitle | Regulatory T cells in patients with systemic lupus erythematosus. | lld:pubmed |
| pubmed-article:16890406 | pubmed:affiliation | Departamento de Inmunología, Facultad de Medicina, UASLP, Ave. V. Carranza 2405, 78210 San Luis Potosí, S.L.P., México. | lld:pubmed |
| pubmed-article:16890406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16890406 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16890406 | lld:pubmed |
