Linked Life Data

16890211

Source:http://linkedlifedata.com/resource/pubmed/id/16890211

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pubmed-article:16890211pubmed:abstractTextReactive oxygen species (ROS) such as superoxide have been linked to the hypertrophic response of the heart to stimuli including angiotensin II (AngII), mechanical stretch, and pressure overload. We have previously demonstrated that cGMP and protein kinase G mediate the antihypertrophic actions of the natriuretic peptides in rat cardiomyocytes and isolated whole hearts. The impact of natriuretic peptides on cardiac ROS generation, however, has not been investigated. We tested the hypothesis that reduced superoxide accumulation contributes to the antihypertrophic action of atrial natriuretic peptide (ANP).lld:pubmed
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pubmed-article:16890211pubmed:articleTitleAntioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes.lld:pubmed
pubmed-article:16890211pubmed:affiliationWynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne 8008, Australia.lld:pubmed
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pubmed-article:16890211pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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