| pubmed-article:16889902 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C0017070 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C0378126 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C0814023 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C1563722 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C1416547 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C1421467 | lld:lifeskim |
| pubmed-article:16889902 | lifeskim:mentions | umls-concept:C1425290 | lld:lifeskim |
| pubmed-article:16889902 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16889902 | pubmed:dateCreated | 2006-9-25 | lld:pubmed |
| pubmed-article:16889902 | pubmed:abstractText | Potassium channels contribute to basic neuronal excitability and modulation. Here, we examined expression patterns of the voltage-gated potassium channel Kv1.4, the nociceptive transduction channels TRPV1 and TRPV2 as well as the putative anti-nociceptive cannabinoid receptor CB1 by immunofluorescence double-labelings in sections of rat dorsal root ganglia (DRGs). Kv1.4, TRPV1 and CB1 were each detected in about one third of neurons (35.7+/-0.5%, 29.4+/-1.1% and 36.4+/-0.5%, respectively, mean diameter 19.1+/-0.3 microm). TRPV2 was present in 4.4+/-0.4% of all neurons that were significantly larger in diameter (27.4+/-0.7 microm; P < 0.001). Antibody double-labeling revealed that the majority of Kv1.4-positive neurons co-expressed TRPV1 (73.9+/-1.5%) whereas none expressed TRPV2. The largest overlap was found with CB1 (93.1+/-0.1%). CB1 expression resembled that seen for Kv1.4 since the majority of neurons expressing CB1-protein also expressed TRPV1 (69.4+/-6.5%) but not TRPV2 (0.6+/-0.3%). When CB1-mRNA was detected using in situ hybridizations an additional subset of larger neurons was labeled including 82.4+/-17.7% of the TRPV2 expressing neurons. However, co-localization of Kv1.4 with CB1-mRNA (92%, mean diameter: 18.5 microm) was essentially the same as with CB1-protein. The almost complete overlap of CB1 and Kv1.4 in nociceptive DRG neurons suggests a functional synergistic action between Kv1.4 and CB1. The potassium channel may have two important roles in nociception. As the molecular basis of A-type current it could be involved in the control of repetitive discharges at peripheral terminals and as a downstream signal transduction site of CB1 in the control of presynaptic transmitter release at central terminals. | lld:pubmed |
| pubmed-article:16889902 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16889902 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16889902 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16889902 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16889902 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16889902 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16889902 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16889902 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16889902 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16889902 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16889902 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:16889902 | pubmed:author | pubmed-author:HennessySS | lld:pubmed |
| pubmed-article:16889902 | pubmed:author | pubmed-author:GreffrathWW | lld:pubmed |
| pubmed-article:16889902 | pubmed:author | pubmed-author:TreedeR-DRD | lld:pubmed |
| pubmed-article:16889902 | pubmed:author | pubmed-author:Saaler-Reinha... | lld:pubmed |
| pubmed-article:16889902 | pubmed:author | pubmed-author:BinzenUU | lld:pubmed |
| pubmed-article:16889902 | pubmed:author | pubmed-author:BausenMM | lld:pubmed |
| pubmed-article:16889902 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16889902 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:16889902 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:16889902 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16889902 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16889902 | pubmed:pagination | 527-39 | lld:pubmed |
| pubmed-article:16889902 | pubmed:meshHeading | pubmed-meshheading:16889902... | lld:pubmed |
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| pubmed-article:16889902 | pubmed:meshHeading | pubmed-meshheading:16889902... | lld:pubmed |
| pubmed-article:16889902 | pubmed:meshHeading | pubmed-meshheading:16889902... | lld:pubmed |
| pubmed-article:16889902 | pubmed:meshHeading | pubmed-meshheading:16889902... | lld:pubmed |
| pubmed-article:16889902 | pubmed:meshHeading | pubmed-meshheading:16889902... | lld:pubmed |
| pubmed-article:16889902 | pubmed:meshHeading | pubmed-meshheading:16889902... | lld:pubmed |
| pubmed-article:16889902 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16889902 | pubmed:articleTitle | Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. | lld:pubmed |
| pubmed-article:16889902 | pubmed:affiliation | Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21, D-55099, Mainz, Germany. | lld:pubmed |
| pubmed-article:16889902 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16889902 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16889902 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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