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pubmed-article:16889636pubmed:abstractTextAntibiotic misuse is associated with emergence of resistance and high expenditures. Fluoroquinolones (FQ) and carbapenems (CP) are drugs with considerable potential of resistance development and its disseminated use is a concern. We undertook a prospective clinical audit to evaluate prescriptions of FQ and CP in a multistep process. Each prescription was unfolded in the following steps: indication for antimicrobial therapy; adequacy of initial prescription, dosage and route; previous cultures; and parenteral-oral transition. There was no antibiotics indication in 8.9% of FQ and 1.5% of CP group (p = 0.07). In CP 25.8% of initial schemes were inappropriate (21% in FQ). Lack of switch to oral therapy comprised 25% of monthly costs of FQ. Inadequacy in initial choice accounted for 13.6% of CP expenses. We concluded that, in spite of infection control restrictive policies, inappropriateness of antibiotic usage is worrisome. Clinical audit in a multistep approach may identify possible flaws in this process.lld:pubmed
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pubmed-article:16889636pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:16889636pubmed:articleTitleCritical steps in fluoroquinolones and carbapenems prescriptions: results from a prospective clinical audit.lld:pubmed
pubmed-article:16889636pubmed:affiliationHospital Infection Control Committee, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. seligman@via-rs.netlld:pubmed
pubmed-article:16889636pubmed:publicationTypeJournal Articlelld:pubmed
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