| pubmed-article:1688928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0034651 | lld:lifeskim |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0034837 | lld:lifeskim |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:1688928 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:1688928 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1688928 | pubmed:dateCreated | 1990-3-6 | lld:pubmed |
| pubmed-article:1688928 | pubmed:abstractText | The concentration dependence and kinetics of ionic currents activated by extracellular adenosine 5'-triphosphate (ATP) were studied in voltage-clamped dorsal root ganglion neurons from rats and bullfrogs. About 40% of neurons of both species responded to ATP with an increase in membrane conductance. The ATP-activated currents were similar in the 2 species, except that currents in rat neurons desensitized faster. In bullfrog neurons, the conductance was half-maximally activated by about 3 microM ATP; at low concentrations, the conductance increased 3- to 7-fold for a doubling in [ATP], suggesting that several ATP molecules must bind in order to activate the current. A steeper concentration-response relationship than expected from 1:1 binding was also seen in rat neurons. The current activated quickly upon application of ATP and decayed quickly when ATP was removed. Activation kinetics were faster at higher [ATP], with time constants decreasing from about 200 msec at 0.3 microM ATP to about 10 msec at 100 microM ATP. Deactivation kinetics (tau approximately 100-200 msec) were independent of the ATP concentration. The rapid activation and deactivation make it seem likely that the ATP-activated current is mediated by direct ligand binding rather than by a second-messenger system. The experimental observations can be mimicked by a simple model in which ATP must bind to 3 identical, noninteracting sites in order to activate a channel. The potency and kinetics of ATP action were voltage-dependent, with hyperpolarization slowing deactivation and increasing ATP's potency. Deactivation kinetics were also sensitive to the concentration of external Ca, becoming faster in higher Ca. | lld:pubmed |
| pubmed-article:1688928 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1688928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688928 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1688928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1688928 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1688928 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:1688928 | pubmed:author | pubmed-author:BeanB PBP | lld:pubmed |
| pubmed-article:1688928 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1688928 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:1688928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1688928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1688928 | pubmed:pagination | 1-10 | lld:pubmed |
| pubmed-article:1688928 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1688928 | pubmed:meshHeading | pubmed-meshheading:1688928-... | lld:pubmed |
| pubmed-article:1688928 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1688928 | pubmed:articleTitle | ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. | lld:pubmed |
| pubmed-article:1688928 | pubmed:affiliation | Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:1688928 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1688928 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1688928 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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