| pubmed-article:16888645 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0815000 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0028470 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16888645 | lifeskim:mentions | umls-concept:C0445450 | lld:lifeskim |
| pubmed-article:16888645 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16888645 | pubmed:dateCreated | 2007-2-15 | lld:pubmed |
| pubmed-article:16888645 | pubmed:abstractText | Protein kinase-B (PKB) and its target, the forkhead transcription factor like 1 (FKHRL1)/FoxO3a, have been suggested as regulators of neurotrophin-mediated cell survival in neuronal cells. We analyzed human neuroblastoma cells and found that FKHRL1 was phosphorylated, suggesting its inactivation. To study FKHRL1 function, we infected SH-EP and NB15 cells with a 4OH-tamoxifen-regulated FKHRL1(A3)ER(tm) transgene. Activation of FKHRL1 promoted cytochrome-c release and caspase-dependent apoptosis. FKHRL1 induced TRAIL and the BH3-only proteins Noxa and Bim, implicating both extrinsic and intrinsic death pathways. However, expression of dnFADD did not inhibit FKHRL1-induced cell death, whereas Bcl2 protected against apoptosis. This excluded the death-receptor pathway and suggested that cell death decision is regulated by Bcl2-rheostat. Importantly, RNAi knockdown of Noxa or Bim decreased apoptosis, indicating that Noxa and Bim cooperate to mediate FKHRL1-induced cell death. We conclude that Noxa and Bim establish a connection between FKHRL1 and mitochondria, and that both BH3-only proteins are critically involved in FKHRL1-induced apoptosis in neuroblastoma. | lld:pubmed |
| pubmed-article:16888645 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16888645 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16888645 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16888645 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16888645 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:16888645 | pubmed:author | pubmed-author:GeigerKK | lld:pubmed |
| pubmed-article:16888645 | pubmed:author | pubmed-author:MeisterBB | lld:pubmed |
| pubmed-article:16888645 | pubmed:author | pubmed-author:AmbrosP FPF | lld:pubmed |
| pubmed-article:16888645 | pubmed:author | pubmed-author:Ausserlechner... | lld:pubmed |
| pubmed-article:16888645 | pubmed:author | pubmed-author:ObexerPP | lld:pubmed |
| pubmed-article:16888645 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16888645 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:16888645 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16888645 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16888645 | pubmed:pagination | 534-47 | lld:pubmed |
| pubmed-article:16888645 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16888645 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:16888645 | pubmed:articleTitle | FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. | lld:pubmed |
| pubmed-article:16888645 | pubmed:affiliation | Tyrolean Cancer Research Institute, Innsbruck, Austria. Petra.Obexer@uibk.ac.at | lld:pubmed |
| pubmed-article:16888645 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16888645 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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