Linked Life Data

16888409

Source:http://linkedlifedata.com/resource/pubmed/id/16888409

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pubmed-article:16888409pubmed:dateCreated2006-8-23lld:pubmed
pubmed-article:16888409pubmed:abstractTextTo clarify the biological behavior of TADG-14/KLK8, we investigated TADG-14/KLK8 mRNA by semiquantitative RT-PCR and hK8 expression by immunohistochemistry using 37 normal endometria and 44 endometrial carcinoma tissues. TADG-14/KLK8 mRNA expression levels were significantly higher in proliferative compared to secretory phase endometria (p = 0.0143). Levels of TADG-14/KLK8 mRNA expression correlated with hK8 protein levels. hK8 was detected in 73.3% (11/15) of endometria with a significantly higher detection rate in the proliferative compared to secretory and atrophic phase endometria (p = 0.0002). High expression of hK8 was found in 61.4% of endometrial carcinomas compared to 35.1% of endometrial tissue samples (p = 0.0187). hK8 expression was significantly higher in stage I (p = 0.0433, 0.0038) and grade 1/2 (G1/2) of the tumors (p = 0.0195, 0.0044). We suggest that expression of TADG-14/KLK8may be regulated by sex steroid hormones in endometria. Our results indicate that elevated TADG-14/KLK8 expression is an early event in endometrial carcinogenesis, and may potentially serve as a useful early biomarker for the detection of endometrial carcinomas in menopausal women.lld:pubmed
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pubmed-article:16888409pubmed:authorpubmed-author:OhamaKosoKlld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:ShigemasaKazu...lld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:NagaiNobutaka...lld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:O'BrienTimoth...lld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:KudoYoshikiYlld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:GuLijunLlld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:TanimotoHirot...lld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:HonghuaJinJlld:pubmed
pubmed-article:16888409pubmed:authorpubmed-author:YunokawaMayuMlld:pubmed
pubmed-article:16888409pubmed:copyrightInfoCopyright (c) 2006 S. Karger AG, Basel.lld:pubmed
pubmed-article:16888409pubmed:issnTypePrintlld:pubmed
pubmed-article:16888409pubmed:volume27lld:pubmed
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pubmed-article:16888409pubmed:pagination274-82lld:pubmed
pubmed-article:16888409pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16888409pubmed:year2006lld:pubmed
pubmed-article:16888409pubmed:articleTitleExpression of tumor-associated differentially expressed Gene-14 (TADG-14/KLK8) and its protein hK8 in uterine endometria and endometrial carcinomas.lld:pubmed
pubmed-article:16888409pubmed:affiliationDepartment of Obstetrics and Gynecology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.lld:pubmed
pubmed-article:16888409pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16888409pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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