| pubmed-article:1688832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1688832 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1688832 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:1688832 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:1688832 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:1688832 | lifeskim:mentions | umls-concept:C0745777 | lld:lifeskim |
| pubmed-article:1688832 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1688832 | lifeskim:mentions | umls-concept:C0276037 | lld:lifeskim |
| pubmed-article:1688832 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1688832 | pubmed:dateCreated | 1990-2-23 | lld:pubmed |
| pubmed-article:1688832 | pubmed:abstractText | We describe a murine IgG1 monoclonal antibody (MAb56), specific for a cell-surface protein structure (MC56 determinant) expressed by the human CEM cell line. A large band of approximately 90 kDa was identified as the main specific component of the MC56 determinant. Such a 90-kDa protein is significantly associated with the drug-sensitive phenotype, its expression being progressively reduced quantitatively in multi-drug-resistant (MDR) variants of CEM cells, according to the extent of drug resistance. In addition, the MC56 determinant is expressed de novo in drug-sensitive revertant cell lines derived from MDR cells and unreactive with the MAb56. The MAb56 shows a high affinity towards the immunizing drug-sensitive CEM cell line (Ka = 1.86 x 10(9) L/mole) while not binding to MDR cell variants. The expression of the MC56 molecule on a variety of human cells and tissues makes such a cellular determinant a candidate as a marker for studying the MDR phenomenon both in vivo and in vitro. | lld:pubmed |
| pubmed-article:1688832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1688832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688832 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1688832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1688832 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1688832 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:MarianiMM | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:MalavasiFF | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:SamoggiaPP | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:MorroneSS | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:BarbuDD | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:SantoniAA | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:CianfrigliaMM | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:CenciarelliCC | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:TombesiMM | lld:pubmed |
| pubmed-article:1688832 | pubmed:author | pubmed-author:AlessioMM | lld:pubmed |
| pubmed-article:1688832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1688832 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1688832 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:1688832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1688832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1688832 | pubmed:pagination | 95-103 | lld:pubmed |
| pubmed-article:1688832 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:meshHeading | pubmed-meshheading:1688832-... | lld:pubmed |
| pubmed-article:1688832 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1688832 | pubmed:articleTitle | Murine monoclonal antibody recognizing a 90-kDa cell-surface determinant selectively lost by multi-drug-resistant variants of CEM cells. | lld:pubmed |
| pubmed-article:1688832 | pubmed:affiliation | Laboratorio di Immunologia, Istituto Superiore di Sanità, Rome, Italy. | lld:pubmed |
| pubmed-article:1688832 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1688832 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1688832 | lld:pubmed |
