| pubmed-article:16887977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16887977 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:16887977 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16887977 | pubmed:dateCreated | 2006-8-4 | lld:pubmed |
| pubmed-article:16887977 | pubmed:abstractText | The ability of dendritic cells (DC) to initiate immune responses or induce immune tolerance is strictly dependent on their maturation state. TNF-alpha plays a pivotal role in the differentiation and maturation of DC. Blockade of TNF-alpha action may arrest DC in an immature state, prolonging their window of tolerogenic opportunity. Immature DC (imDC) were transfected with recombinant adenovirus to express soluble TNF-alpha receptor type I (sTNFRI), a specific inhibitor of TNF-alpha. The capacity of sTNFRI gene-modified imDC (DC-sTNFRI) to induce immune tolerance was analyzed. sTNFRI expression renders imDC resistant to maturation induction and impairs their capacity to migrate or present Ag. This process leads to induction of allogeneic T cell hyporesponsiveness and the generation of IL-10-producing T regulatory-like cells. In vivo pretreatment of transplant recipients with DC-sTNFRI induces long-term survival of cardiac allografts in 50% of cases, and leads to a substantial increase in the generation of microchimerism and T regulatory cell numbers. Thus, blockade of TNF-alpha action by sTNFRI genetic modification can inhibit the maturation of DC and potentiate the in vivo capacity of imDC to induce donor-specific immune tolerance and prolong allograft survival. | lld:pubmed |
| pubmed-article:16887977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16887977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16887977 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16887977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16887977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16887977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16887977 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16887977 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:WangJianliJ | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:ZhengShusenS | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:ZhangWeipingW | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:CaoXuetaoX | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:ZhangMinghuiM | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:LiuYushanY | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:WangQuanxingQ | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:ChenGuoyouG | lld:pubmed |
| pubmed-article:16887977 | pubmed:author | pubmed-author:DingGuoshanG | lld:pubmed |
| pubmed-article:16887977 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16887977 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16887977 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:16887977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16887977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16887977 | pubmed:pagination | 2175-85 | lld:pubmed |
| pubmed-article:16887977 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16887977 | pubmed:meshHeading | pubmed-meshheading:16887977... | lld:pubmed |
| pubmed-article:16887977 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16887977 | pubmed:articleTitle | Induction of allospecific tolerance by immature dendritic cells genetically modified to express soluble TNF receptor. | lld:pubmed |
| pubmed-article:16887977 | pubmed:affiliation | Institute of Immunology, Second Military Medical University, 800 Yiangyin Road, Shanghai 200433, People's Republic of China. | lld:pubmed |
| pubmed-article:16887977 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16887977 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:21937 | entrezgene:pubmed | pubmed-article:16887977 | lld:entrezgene |
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