| pubmed-article:1688684 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0019189 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0279030 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C1579762 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:1688684 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:1688684 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1688684 | pubmed:dateCreated | 1990-2-16 | lld:pubmed |
| pubmed-article:1688684 | pubmed:abstractText | Nineteen patients with chronic non-A, non-B hepatitis (CH-NANB) and 24 patients with chronic hepatitis B (CH-B) were treated with interferons, and the therapeutic and biological responses of the two groups (CH-NANB and CH-B) were compared. All patients had had sustained elevations in serum glutamic pyruvic transaminase (sGPT) levels for more than 6 months and were proven to have chronic hepatitis by liver biopsy. alpha-Interferon (IFN-alpha) or beta-interferon (IFN-beta) was administered in low doses of 3 to 6 mega international units (MIU) daily for 4 wk. Liver biopsies were taken from 13 CH-NANB and 14 CH-B subjects just before and immediately after treatment, and histological findings were assessed by the histology activity index (HAI) score. SGPT levels decreased much more rapidly and markedly in CH-NANB than in CH-B during IFN therapy (p less than 0.01). The HAI score decreased 3.5 points in CH-NANB and 1.0 point in CH-B between pretreatment and posttreatment. Serum beta 2-microglobulin (beta 2-MG) increased in both types of chronic hepatitis during treatment, but the rate of elevation was significantly less in CH-NANB than in CH-B (p less than 0.001). beta 2-MG expression on hepatocytes stained by the PAP method was almost identical in CH-NANB before and after treatment, whereas it increased steadily in CH-B. The serum 2',5'-oligoadenylate synthetase level increased in both types of hepatitis on IFN administration. These results suggest that, in IFN treatment for CH-NANB, the antiviral actions of IFNs may play a very important role in reducing the activity of chronic hepatitis. | lld:pubmed |
| pubmed-article:1688684 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1688684 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688684 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1688684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1688684 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1688684 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1688684 | pubmed:issn | 0002-9270 | lld:pubmed |
| pubmed-article:1688684 | pubmed:author | pubmed-author:NakanoYY | lld:pubmed |
| pubmed-article:1688684 | pubmed:author | pubmed-author:KiyosawaKK | lld:pubmed |
| pubmed-article:1688684 | pubmed:author | pubmed-author:TanakaEE | lld:pubmed |
| pubmed-article:1688684 | pubmed:author | pubmed-author:SodeyamaTT | lld:pubmed |
| pubmed-article:1688684 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1688684 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:1688684 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1688684 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1688684 | pubmed:pagination | 24-9 | lld:pubmed |
| pubmed-article:1688684 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:meshHeading | pubmed-meshheading:1688684-... | lld:pubmed |
| pubmed-article:1688684 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1688684 | pubmed:articleTitle | Comparative study of clinical, histological, and immunological responses to interferon therapy in type non-A, non-B, and type B chronic hepatitis. | lld:pubmed |
| pubmed-article:1688684 | pubmed:affiliation | Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan. | lld:pubmed |
| pubmed-article:1688684 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1688684 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1688684 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1688684 | lld:pubmed |
