| pubmed-article:16886565 | pubmed:abstractText | Despite of belonging to different chemical groups all nonsteroidal antiinflammatory drugs (NSAIDs) exert on antiinflammatory, antypyretic and analgetic effects inhibiting prostaglandin synthesis, preciseley inhibiting first enzyme in arachidonic acid- cyclooxygenase. The aim of the study was to investigate the influence of NSAIDs on nitric oxide synthesis and releasing to bloodstream Acetylsalicic acid (ASA) and diclofenac as COX-1 and COX-2 inhibitors and nimesulide as selective COX-2 inhibitor were used in study. | lld:pubmed |
