| pubmed-article:16885342 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16885342 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:16885342 | lifeskim:mentions | umls-concept:C0525039 | lld:lifeskim |
| pubmed-article:16885342 | lifeskim:mentions | umls-concept:C0026565 | lld:lifeskim |
| pubmed-article:16885342 | lifeskim:mentions | umls-concept:C0596244 | lld:lifeskim |
| pubmed-article:16885342 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:16885342 | lifeskim:mentions | umls-concept:C2936267 | lld:lifeskim |
| pubmed-article:16885342 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:16885342 | pubmed:dateCreated | 2006-8-3 | lld:pubmed |
| pubmed-article:16885342 | pubmed:abstractText | This study uses a base excision repair (BER)-deficient model, the DNA polymerase beta heterozygous mouse, to investigate the effect of BER deficiency on tumorigenicity and aging. Aged beta-pol(+/-) mice express 50% less beta-pol transcripts and protein (P < 0.05) than aged beta-pol(+/+) mice, showing maintenance of the heterozygous state over the life span of the mouse. This reduction in beta-pol expression was not associated with an increase in mutation rate but was associated with a 100% increase in the onset of hypoploidy. Aged beta-pol(+/-) mice exhibited a 6.7-fold increase in developing lymphoma (P < 0.01). Accordingly, 38% of beta-pol(+/-) mice exhibited lymphoid hyperplasia, whereas none of the beta-pol(+/+) exhibited this phenotype. beta-pol(+/-) mice were also more likely to develop adenocarcinoma (2.7-fold increase; P < 0.05) and more likely to develop multiple tumors, as 20% of the beta-pol(+/-) animals died bearing multiple tumors compared with only 5% of the beta-pol(+/+) animals (P < 0.05). In spite of accelerated tumor development, no gross effect of beta-pol heterozygosity was seen with respect to life span. However, the survival curves for the beta-pol(+/+) and beta-pol(+/-) mice are not identical. A maximum likelihood estimation analysis showed a modest but significant (P < 0.05) acceleration of the age-dependent mortality rate in beta-pol(+/-) mice. Thus, the beta-pol(+/-) mouse represents a model in which mortality rate and tumor development are accelerated and provides evidence supporting the role of genomic maintenance in both aging and carcinogenesis. | lld:pubmed |
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| pubmed-article:16885342 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16885342 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16885342 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16885342 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16885342 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16885342 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16885342 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:VijgJanJ | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:WilsonSamuel... | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:TuckerJames... | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:CabelofDiane... | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:HeydariAhmad... | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:MatherlyLarry... | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:NyskaAbrahamA | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:IkenoYujiY | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:RichardsonArl... | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:BusuttilRita... | lld:pubmed |
| pubmed-article:16885342 | pubmed:author | pubmed-author:AnyangweNjwen... | lld:pubmed |
| pubmed-article:16885342 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16885342 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16885342 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:16885342 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16885342 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16885342 | pubmed:pagination | 7460-5 | lld:pubmed |
| pubmed-article:16885342 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:meshHeading | pubmed-meshheading:16885342... | lld:pubmed |
| pubmed-article:16885342 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16885342 | pubmed:articleTitle | Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. | lld:pubmed |
| pubmed-article:16885342 | pubmed:affiliation | Karmanos Cancer Institute, Developmental Therapeutics Program, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA. d.cabelof@wayne.edu | lld:pubmed |
| pubmed-article:16885342 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16885342 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:18970 | entrezgene:pubmed | pubmed-article:16885342 | lld:entrezgene |
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