| pubmed-article:16884330 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C0025611 | lld:lifeskim |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:16884330 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:16884330 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16884330 | pubmed:dateCreated | 2006-8-3 | lld:pubmed |
| pubmed-article:16884330 | pubmed:abstractText | The US is currently experiencing a grave epidemic of methamphetamine use as a recreational drug, and the risk for HIV-1 infection attributable to methamphetamine use continues to increase. Recent studies show a high prevalence of HIV infection among methamphetamine users. Dendritic cells (DCs) are potent antigen presenting cells that are the initial line of defense against HIV-1 infection. In addition, DCs also serve as reservoirs for HIV-1 and function at the interface between the adaptive and the innate immune systems, which recognize and internalize pathogens and subsequently activate T cells. Exposure to methamphetamine results in modulation of immune functional parameters that are necessary for host defense. Chronic methamphetamine use can cause psychiatric co-morbidity, neurological complications, and can alter normal biological processes and immune functions. Limited information is available on the mechanisms by which methamphetamine may influence immune function. This study explores the effect of methamphetamine on a specific array of genes that may modulate immune function. We hypothesize that methamphetamine treatment results in the immunomodulation of DC functions, leading to dysregulation of the immune system of the infected host. This suggests that methamphetamine has a role as a cofactor in the pathogenesis of HIV-1. | lld:pubmed |
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| pubmed-article:16884330 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16884330 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16884330 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16884330 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16884330 | pubmed:issn | 1177-1062 | lld:pubmed |
| pubmed-article:16884330 | pubmed:author | pubmed-author:SchwartzStanl... | lld:pubmed |
| pubmed-article:16884330 | pubmed:author | pubmed-author:AalinkeelRavi... | lld:pubmed |
| pubmed-article:16884330 | pubmed:author | pubmed-author:MahajanSupriy... | lld:pubmed |
| pubmed-article:16884330 | pubmed:author | pubmed-author:NairMadhavan... | lld:pubmed |
| pubmed-article:16884330 | pubmed:author | pubmed-author:HuZihuaZ | lld:pubmed |
| pubmed-article:16884330 | pubmed:author | pubmed-author:ReynoldsJessi... | lld:pubmed |
| pubmed-article:16884330 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16884330 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:16884330 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16884330 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16884330 | pubmed:pagination | 257-69 | lld:pubmed |
| pubmed-article:16884330 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16884330 | pubmed:meshHeading | pubmed-meshheading:16884330... | lld:pubmed |
| pubmed-article:16884330 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16884330 | pubmed:articleTitle | Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesis. | lld:pubmed |
| pubmed-article:16884330 | pubmed:affiliation | Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, Buffalo, New York 14203, USA. smahajan@buffalo.edu | lld:pubmed |
| pubmed-article:16884330 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16884330 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16884330 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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