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pubmed-article:1687665pubmed:abstractTextThe present study demonstrates many dynorphin (DYN)-immunoreactive fibers and presumed presynaptic terminals in rat lumbar ventral horn. The fibers and terminals seem to arise largely from DYN-containing intrinsic neurons in the dorsal horn. The majority of the presumed terminals closely surround a subpopulation of motoneurons that tend to be located in flexor motoneuron columns. Acute C fiber, but not A fiber, primary afferent stimulation depletes the ventral horn DYN immunostaining. We interpret these findings to indicate that the spinal DYN neurons are well positioned to serve both as modulators of nociceptive input and as interneurons in motor reflexes. We further hypothesize that the depletion of DYN-immunoreactivity that follows either acute C fiber stimulation or intense nociceptive stimuli may be the trigger for the upregulation in spinal cord DYN that occurs in models of chronic pain states.lld:pubmed
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pubmed-article:1687665pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1687665pubmed:articleTitleUnmyelinated primary afferent fiber stimulation depletes dynorphin A (1-8) immunoreactivity in rat ventral horn.lld:pubmed
pubmed-article:1687665pubmed:affiliationDepartment of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77550.lld:pubmed
pubmed-article:1687665pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1687665pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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