| pubmed-article:16866310 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16866310 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16866310 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:16866310 | lifeskim:mentions | umls-concept:C0010092 | lld:lifeskim |
| pubmed-article:16866310 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:16866310 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:16866310 | pubmed:dateCreated | 2006-7-26 | lld:pubmed |
| pubmed-article:16866310 | pubmed:abstractText | In this paper we review three intra-luteal factors and their roles in the corpus luteum (CL). Insulin-like growth factor (IGF)-I, together with its receptor and IGF-binding proteins (IGFBPs), represent an important control system in the CL. IGF-I is a product of small luteal cells and has steroidogenic (i.e. luteotrophic) actions on large luteal cells via the type I receptor, while IGFBPs (e.g. BP-2 and 3; small cells) generally inhibit IGF-Is actions. IGF-I is particularly important in early CL development (up to day 7 of the oestrous cycle) in the pig. Tumour necrosis factor (TNF)-alpha is a product of luteal macrophages that infiltrate CLs in increasing numbers as the cycle progresses. TNF-alpha has been shown to play an important role in luteolysis, but we hypothesise that in the pig, this factor plays an additional role during the mid-luteal phase (days 7-13) in promoting the acquisition of luteal sensitivity to the luteolytic actions of prostaglandin (PG)F2alpha (= luteolytic sensitivity; LS). Endothelin (ET)-1 is a product of (luteal) endothelial cells, and along with its receptors (ETA and ETB) and endothelin-converting enzyme (ECE)-1, represent an intra-luteal system that also plays a role in luteolysis, in association with PGF2alpha. Since TNF-alpha induces endothelial cells to secrete ET-1, we hypothesise that ET-1 mediates the sensitising effects of TNF-alpha on the porcine CL during the mid-luteal phase (days 7-13). Finally, we hypothesise that TNF-alpha and/or ET-1 act to up-regulate luteal protein kinase C (e.g. isoforms betaII and epsilon) activity and thereby sensitises luteal cells to PGF2alpha. | lld:pubmed |
| pubmed-article:16866310 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16866310 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16866310 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16866310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16866310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16866310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16866310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16866310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16866310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16866310 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16866310 | pubmed:author | pubmed-author:RoseLL | lld:pubmed |
| pubmed-article:16866310 | pubmed:author | pubmed-author:FuKK | lld:pubmed |
| pubmed-article:16866310 | pubmed:author | pubmed-author:GadsbyJJ | lld:pubmed |
| pubmed-article:16866310 | pubmed:author | pubmed-author:Sriperumbudur... | lld:pubmed |
| pubmed-article:16866310 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:16866310 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16866310 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16866310 | pubmed:pagination | 69-83 | lld:pubmed |
| pubmed-article:16866310 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16866310 | pubmed:meshHeading | pubmed-meshheading:16866310... | lld:pubmed |
| pubmed-article:16866310 | pubmed:meshHeading | pubmed-meshheading:16866310... | lld:pubmed |
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| pubmed-article:16866310 | pubmed:meshHeading | pubmed-meshheading:16866310... | lld:pubmed |
| pubmed-article:16866310 | pubmed:meshHeading | pubmed-meshheading:16866310... | lld:pubmed |
| pubmed-article:16866310 | pubmed:meshHeading | pubmed-meshheading:16866310... | lld:pubmed |
| pubmed-article:16866310 | pubmed:meshHeading | pubmed-meshheading:16866310... | lld:pubmed |
| pubmed-article:16866310 | pubmed:meshHeading | pubmed-meshheading:16866310... | lld:pubmed |
| pubmed-article:16866310 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16866310 | pubmed:articleTitle | The role of intra-luteal factors in the control of the porcine corpus luteum. | lld:pubmed |
| pubmed-article:16866310 | pubmed:affiliation | Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. John_Gadsby@ncsu.edu | lld:pubmed |
| pubmed-article:16866310 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16866310 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16866310 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16866310 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16866310 | lld:pubmed |
