pubmed-article:16864657 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16864657 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
pubmed-article:16864657 | lifeskim:mentions | umls-concept:C0184512 | lld:lifeskim |
pubmed-article:16864657 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
pubmed-article:16864657 | lifeskim:mentions | umls-concept:C1366537 | lld:lifeskim |
pubmed-article:16864657 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
pubmed-article:16864657 | lifeskim:mentions | umls-concept:C0596963 | lld:lifeskim |
pubmed-article:16864657 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:16864657 | pubmed:dateCreated | 2006-8-1 | lld:pubmed |
pubmed-article:16864657 | pubmed:abstractText | Chemoattractants like f-Met-Leu-Phe (fMLP) induce neutrophils to polarize by triggering divergent signals that promote the formation of protrusive filamentous actin (F-actin; frontness) and RhoA-dependent actomyosin contraction (backness). Frontness locally inhibits backness and vice versa. In neutrophil-like HL60 cells, blocking phosphatidylinositol-3,4,5-tris-phosphate (PIP3) accumulation with selective inhibitors of PIP3 synthesis completely prevents fMLP from activating a PIP3-dependent kinase and Cdc42 but not from stimulating F-actin accumulation. PIP3-deficient cells show reduced fMLP-dependent Rac activity and unstable pseudopods, which is consistent with the established role of PIP3 as a mediator of positive feedback pathways that augment Rac activation at the front. Surprisingly, such cells also show reduced RhoA activation and RhoA-dependent contraction at the trailing edge, leading to the formation of multiple lateral pseudopods. Cdc42 mediates PIP3's positive effect on RhoA activity. Thus, PIP3 and Cdc42 maintain stable polarity with a single front and a single back not only by strengthening pseudopods but also, at longer range, by promoting RhoA-dependent actomyosin contraction at the trailing edge. | lld:pubmed |
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pubmed-article:16864657 | pubmed:language | eng | lld:pubmed |
pubmed-article:16864657 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16864657 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:16864657 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:16864657 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16864657 | pubmed:month | Jul | lld:pubmed |
pubmed-article:16864657 | pubmed:issn | 0021-9525 | lld:pubmed |
pubmed-article:16864657 | pubmed:author | pubmed-author:WallJ CJC | lld:pubmed |
pubmed-article:16864657 | pubmed:author | pubmed-author:ShokatKevan... | lld:pubmed |
pubmed-article:16864657 | pubmed:author | pubmed-author:HahnKlaus MKM | lld:pubmed |
pubmed-article:16864657 | pubmed:author | pubmed-author:GovaertsCedri... | lld:pubmed |
pubmed-article:16864657 | pubmed:author | pubmed-author:BourneHenry... | lld:pubmed |
pubmed-article:16864657 | pubmed:author | pubmed-author:Van... | lld:pubmed |
pubmed-article:16864657 | pubmed:author | pubmed-author:KnightZachary... | lld:pubmed |
pubmed-article:16864657 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:16864657 | pubmed:day | 31 | lld:pubmed |
pubmed-article:16864657 | pubmed:volume | 174 | lld:pubmed |
pubmed-article:16864657 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16864657 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16864657 | pubmed:pagination | 437-45 | lld:pubmed |
pubmed-article:16864657 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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