| pubmed-article:16857277 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16857277 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
| pubmed-article:16857277 | lifeskim:mentions | umls-concept:C0025611 | lld:lifeskim |
| pubmed-article:16857277 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16857277 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:16857277 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16857277 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:16857277 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16857277 | pubmed:dateCreated | 2006-8-21 | lld:pubmed |
| pubmed-article:16857277 | pubmed:abstractText | Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse. | lld:pubmed |
| pubmed-article:16857277 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16857277 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16857277 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16857277 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16857277 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16857277 | pubmed:issn | 0166-4328 | lld:pubmed |
| pubmed-article:16857277 | pubmed:author | pubmed-author:NittaAtsumiA | lld:pubmed |
| pubmed-article:16857277 | pubmed:author | pubmed-author:YamadaKiyofum... | lld:pubmed |
| pubmed-article:16857277 | pubmed:author | pubmed-author:NabeshimaTosh... | lld:pubmed |
| pubmed-article:16857277 | pubmed:author | pubmed-author:NakajimaAkira... | lld:pubmed |
| pubmed-article:16857277 | pubmed:author | pubmed-author:YanYijinY | lld:pubmed |
| pubmed-article:16857277 | pubmed:author | pubmed-author:MizunoTomokoT | lld:pubmed |
| pubmed-article:16857277 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16857277 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:16857277 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:16857277 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16857277 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16857277 | pubmed:pagination | 39-46 | lld:pubmed |
| pubmed-article:16857277 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16857277 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16857277 | pubmed:articleTitle | Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. | lld:pubmed |
| pubmed-article:16857277 | pubmed:affiliation | Department of Neuropsychopharmacology & Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan. | lld:pubmed |
| pubmed-article:16857277 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16857277 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16857277 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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