| pubmed-article:16853585 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16853585 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:16853585 | lifeskim:mentions | umls-concept:C0039778 | lld:lifeskim |
| pubmed-article:16853585 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16853585 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:16853585 | pubmed:dateCreated | 2006-7-20 | lld:pubmed |
| pubmed-article:16853585 | pubmed:abstractText | The reaction mechanism of human deoxyribonucleotidase (dN) is studied using high-level quantum-chemical methods. dN catalyzes the dephosphorylation of deoxyribonucleoside monophosphates (dNMPs) to their nucleoside form in human cells. Large quantum models are employed (99 atoms) based on a recent X-ray crystal structure. The calculations support the proposed mechanism in which Asp41 performs a nucleophilic attack on the phosphate to form a phospho-enzyme intermediate. Asp43 acts in the first step as an acid, protonating the leaving nucleoside, and in the second step as a base, deprotonating the lytic water. No pentacoordinated intermediates could be located. | lld:pubmed |
| pubmed-article:16853585 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16853585 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16853585 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16853585 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16853585 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16853585 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16853585 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16853585 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16853585 | pubmed:issn | 1520-6106 | lld:pubmed |
| pubmed-article:16853585 | pubmed:author | pubmed-author:NordlundPärP | lld:pubmed |
| pubmed-article:16853585 | pubmed:author | pubmed-author:HimoFahmiF | lld:pubmed |
| pubmed-article:16853585 | pubmed:author | pubmed-author:Rinaldo-Matth... | lld:pubmed |
| pubmed-article:16853585 | pubmed:author | pubmed-author:GuoJing-DongJ... | lld:pubmed |
| pubmed-article:16853585 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16853585 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:16853585 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:16853585 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16853585 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16853585 | pubmed:pagination | 20004-8 | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:meshHeading | pubmed-meshheading:16853585... | lld:pubmed |
| pubmed-article:16853585 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16853585 | pubmed:articleTitle | Reaction mechanism of deoxyribonucleotidase: a theoretical study. | lld:pubmed |
| pubmed-article:16853585 | pubmed:affiliation | Theoretical Chemistry, Department of Biotechnology, Royal Institute of Technology, ALBANOVA, SE-106 91 Stockholm, Sweden. | lld:pubmed |
| pubmed-article:16853585 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16853585 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16853585 | lld:pubmed |
