| pubmed-article:16847012 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16847012 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:16847012 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:16847012 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16847012 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16847012 | lifeskim:mentions | umls-concept:C1413906 | lld:lifeskim |
| pubmed-article:16847012 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16847012 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16847012 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:16847012 | pubmed:dateCreated | 2006-8-15 | lld:pubmed |
| pubmed-article:16847012 | pubmed:abstractText | Genetic factors play an important role in the etiology of late-onset Alzheimer's disease (LOAD). We tested gene-centric single nucleotide polymorphisms (SNPs) on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with LOAD. SNP rs4878104 was significantly associated with LOAD in our discovery case-control sample set (WU) and replicated in each of two initial validation case-control sample sets (P<0.05, UK1, SD). The risk-allele frequency of this SNP showed a similar direction in three other case-control sample sets. A meta-analysis of the six sample sets combined, totaling 2012 cases and 2336 controls, showed an allelic P-value of 0.0016 and an odds ratio (OR) of 0.87 (95%CI: 0.79-0.95). Minor allele homozygotes had a consistently lower risk than major allele homozygotes in the discovery and initial two replication sample sets, which remained significant in the meta-analysis of all six sample sets (OR=0.7, 95%CI: 0.58-0.85), whereas the risk for heterozygous subjects was not significantly different from that of major allele homozygotes. A second SNP, rs4877365, which is in high linkage disequilibrium with rs4878104 (r2=0.64), was also significantly associated with LOAD (meta P=0.0017 in the initial three sample sets). Furthermore, DAPK1 transcripts show differential allelic gene expression, and both rs4878104 and rs4877365 were significantly associated with DAPK1 allele-specific expression (P=0.015 to <0.0001). These data suggest that genetic variation in DAPK1 modulates susceptibility to LOAD. | lld:pubmed |
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| pubmed-article:16847012 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16847012 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16847012 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16847012 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16847012 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16847012 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:MorrisJohn... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:BrayneCarolC | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:ThalLeon JLJ | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:RubinszteinDa... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:LovestoneSimo... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:GoateAlisonA | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:HardyJohnJ | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:OwenMichaelM | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:AbrahamRichar... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:WilliamsJulie... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:O'DonovanMich... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:WhiteThomas... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:RowlandCharle... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:LiYonghongY | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:HollingworthP... | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:GrupeAndrewA | lld:pubmed |
| pubmed-article:16847012 | pubmed:author | pubmed-author:NowotnyPetraP | lld:pubmed |
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| pubmed-article:16847012 | pubmed:author | pubmed-author:ToombsTimothy... | lld:pubmed |
| pubmed-article:16847012 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16847012 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16847012 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:16847012 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16847012 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16847012 | pubmed:pagination | 2560-8 | lld:pubmed |
| pubmed-article:16847012 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16847012 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16847012 | pubmed:articleTitle | DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. | lld:pubmed |
| pubmed-article:16847012 | pubmed:affiliation | Celera Diagnostics, Alameda, CA 94502, USA. yonghong.li@celeradiagnostics.com | lld:pubmed |
| pubmed-article:16847012 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16847012 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16847012 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:16847012 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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